Morin (flavonol)

Morin
Skeletal formula of morin
Ball-and-stick model of the morin molecule
Names
IUPAC name
2-(2,4-Dihydroxyphenyl)-3,5,7-trihydroxychromen-4-one
Other names
Aurantica
Al-Morin
Morin hydrate
Calico Yellow
Toxylon pomiferum
Bois d'arc
Osage orange extract
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard 100.210.295
KEGG
Properties
C15H10O7
Molar mass 302.24 g·mol−1
Density 1.799 g/mL
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☑Y verify (what is ☑Y☒N ?)
Infobox references

Morin is a yellow chemical compound that can be isolated from Maclura pomifera (Osage orange), Maclura tinctoria (old fustic) and from leaves of Psidium guajava (common guava).[1] In a preclinical in vitro study, morin was found to be a weak inhibitor of fatty acid synthase with an IC50 of 2.33 μM.[2] Morin was also found to inhibit amyloid formation by islet amyloid polypeptide (or amylin) and disaggregate amyloid fibers.[3]

Morin can be used to test for the presence of aluminium or tin in a solution, since it forms characteristically fluorescent coordination complexes with them.

Glycosides

References

  1. 1 2 3 Bacteriostatic effect of flavonoids isolated from leaves of Psidium guajava on fish pathogens. Rattanachaikunsopon Pongsak and Phumkhachorn Parichat, INIST:19087798
  2. ↑ Tian, WX (February 2006). "Inhibition of Fatty Acid Synthase by Polyphenols". Current Medicinal Chemistry. 13 (8): 967–977. doi:10.2174/092986706776361012. PMID 16611078.
  3. ↑ Noor, H; Cao, P; Raleigh, DP (March 2012). "Morin hydrate inhibits amyloid formation by islet amyloid polypeptide and disaggregates amyloid fibers". Protein Science. 21 (3): 373–82. doi:10.1002/pro.2023. PMC 3375438. PMID 22238175.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.