Methylated-thiol-coenzyme M methyltransferase

Methylated-thiol-coenzyme M methyltransferase (EC 2.1.1.251, mtsA (gene)) is an enzyme with systematic name methylated-thiol:coenzyme M methyltransferase.[1][2][3] This enzyme catalyses the following chemical reaction:

methanethiol + coenzyme M ⇌ methyl-CoM + hydrogen sulfide (overall reaction)

 

 

 

 

(1)

methanethiol + [Co(I) methylated-thiol-specific corrinoid protein] ⇌ [methyl-Co(III) methylated-thiol-specific corrinoid protein] + hydrogen sulfide

 

 

 

 

(1a)

[methyl-Co(III) methylated-thiol-specific corrinoid protein] + coenzyme M ⇌ methyl-CoM + [Co(I) methylated-thiol-specific corrinoid protein]

 

 

 

 

(1b)

Methylated-thiol-coenzyme M methyltransferase
Identifiers
EC number 2.1.1.251
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

This enzyme involved in methanogenesis from methylated thiols, such as methanethiol, dimethyl sulfide, and 3-S-methylmercaptopropionate.

References

  1. ↑ Paul, L.; Krzycki, J.A. (1996). "Sequence and transcript analysis of a novel Methanosarcina barkeri methyltransferase II homolog and its associated corrinoid protein homologous to methionine synthase". J. Bacteriol. 178: 6599–6607. doi:10.1128/jb.178.22.6599-6607.1996. PMC 178547. PMID 8932317.
  2. ↑ Tallant, T.C.; Krzycki, J.A. (1997). "Methylthiol:coenzyme M methyltransferase from Methanosarcina barkeri, an enzyme of methanogenesis from dimethylsulfide and methylmercaptopropionate". J. Bacteriol. 179: 6902–6911. doi:10.1128/jb.179.22.6902-6911.1997. PMC 179627. PMID 9371433.
  3. ↑ Tallant, T.C.; Paul, L.; Krzycki, J.A. (2001). "The MtsA subunit of the methylthiol:coenzyme M methyltransferase of Methanosarcina barkeri catalyses both half-reactions of corrinoid-dependent dimethylsulfide: coenzyme M methyl transfer". J. Biol. Chem. 276: 4485–4493. doi:10.1074/jbc.m007514200. PMID 11073950.
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