Methanol dehydrogenase (nicotinoprotein)

Methanol dehydrogenase (nicotinoprotein)
Identifiers
EC number 1.1.99.37
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Methanol dehydrogenase (nicotinoprotein) (EC 1.1.99.37, NDMA-dependent methanol dehydrogenase, nicotinoprotein methanol dehydrogenase, methanol:N,N-dimethyl-4-nitrosoaniline oxidoreductase) is an enzyme with systematic name methanol:acceptor oxidoreductase.[1][2][3][4][5] This enzyme catalyses the following chemical reaction

methanol + acceptor formaldehyde + reduced acceptor

This enzyme contains Zn2+ and Mg2+. N

References

  1. ↑ Vonck, J.; Arfman, N.; De Vries, G.E.; Van Beeumen, J.; Van Bruggen, E.F.; Dijkhuizen, L. (1991). "Electron microscopic analysis and biochemical characterization of a novel methanol dehydrogenase from the thermotolerant Bacillus sp. C1". J. Biol. Chem. 266 (6): 3949–3954. PMID 1995642.
  2. ↑ Van Ophem, P.W.; Van Beeumen, J.; Duine, J.A. (1993). "Nicotinoprotein [NAD(P)-containing] alcohol/aldehyde oxidoreductases. Purification and characterization of a novel type from Amycolatopsis methanolica". Eur. J. Biochem. 212 (3): 819–826. doi:10.1111/j.1432-1033.1993.tb17723.x. PMID 8385013.
  3. ↑ Bystrykh, L.V.; Vonck, J.; van Bruggen, E.F.; van Beeumen, J.; Samyn, B.; Govorukhina, N.I.; Arfman, N.; Duine, J.A.; Dijkhuizen, L. (1993). "Electron microscopic analysis and structural characterization of novel NADP(H)-containing methanol: N,N′-dimethyl-4-nitrosoaniline oxidoreductases from the gram-positive methylotrophic bacteria Amycolatopsis methanolica and Mycobacterium gastri MB19". J. Bacteriol. 175 (6): 1814–1822. PMC 203978. PMID 8449887.
  4. ↑ Hektor, H.J.; Kloosterman, H.; Dijkhuizen, L. (2002). "Identification of a magnesium-dependent NAD(P)(H)-binding domain in the nicotinoprotein methanol dehydrogenase from Bacillus methanolicus". J. Biol. Chem. 277 (49): 46966–46973. doi:10.1074/jbc.M207547200. PMID 12351635.
  5. ↑ Park, H.; Lee, H.; Ro, Y.T.; Kim, Y.M. (2010). "Identification and functional characterization of a gene for the methanol : N,N′-dimethyl-4-nitrosoaniline oxidoreductase from Mycobacterium sp. strain JC1 (DSM 3803)". Microbiology. 156 (Pt 2): 463–471. doi:10.1099/mic.0.034124-0. PMID 19875438.
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