| City |
Country |
Airport |
Notes |
| Buenos Aires | Argentina | Ministro Pistarini International Airport | |
| Mendoza | Argentina | Governor Francisco Gabrielli International Airport | |
| La Paz | Bolivia | El Alto International Airport | Operated by Avianca Ecuador |
| Santa Cruz de la Sierra | Bolivia | Viru Viru International Airport | Operated by Avianca Ecuador |
| Brasilia | Brazil | Brasilia International Airport | Terminated |
| Porto Alegre | Brazil | Salgado Filho International Airport | |
| Rio de Janeiro | Brazil | Galeao International Airport | |
| Sao Paulo | Brazil | São Paulo-Guarulhos International Airport | |
| Antofagasta | Chile | Cerro Moreno International Airport | Terminated |
| Santiago | Chile | Comodoro Arturo Merino Benitez International Airport | Operated by Avianca Costa Rica |
| Bogotá | Colombia | El Dorado International Airport | |
| Cali | Colombia | Alfonso Bonilla Aragón International Airport | |
| Medellín | Colombia | José María Córdova International Airport | |
| San José de Costa Rica | Costa Rica | Juan Santamaría International Airport | |
| Havana | Cuba | Jose Marti International Airport | |
| Punta Cana | Dominican Republic | Punta Cana International Airport | |
| Guayaquil | Ecuador | Jose Joaquin de Olmedo International Airport | Operated by Avianca Ecuador |
| Quito | Ecuador | Mariscal Sucre International Airport | Operated by Avianca Ecuador |
| San Salvador | El Salvador | Cuscatlan International Airport | |
| Cancun | Mexico | Cancun International Airport | |
| Mexico City | Mexico | Benito Juarez International Airport | |
| Asuncion | Paraguay | Silvio Pettirossi International Airport | |
| Arequipa | Peru | Rodríguez Ballón International Airport | |
| Chiclayo | Peru | Cap. FAP José A. Quiñones Gonzáles International Airport | Terminated |
| Cusco | Peru | Alejandro Velasco Astete International Airport | |
| Juliaca | Peru | Inca Manco Cápac International Airport | |
| Iquitos | Peru | Coronel FAP Francisco Secada Vignetta International Airport | Terminated |
| Lima | Peru | Jorge Chávez International Airport | |
| Piura | Peru | Cap. FAP Guillermo Concha Iberico International Airport | |
| Puerto Maldonado | Peru | Padre Aldamiz International Airport | |
| Tarapoto | Peru | Cad. FAP Guillermo del Castillo Paredes Airport | Terminated |
| Trujillo | Peru | Cap. FAP Carlos Martínez de Pinillos International Airport | |
| Miami | United States | Miami International Airport | |
| Orlando | United States | Orlando International Airport | |
| Montevideo | Uruguay | Carrasco International Airport | |
| Caracas | Venezuela | Simón Bolívar International Airport | Terminated |
