Limonene-1,2-diol dehydrogenase

Limonene-1,2-diol dehydrogenase
Identifiers
EC number 1.1.1.297
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Limonene-1,2-diol dehydrogenase (EC 1.1.1.297, NAD+-dependent limonene-1,2-diol dehydrogenase) is an enzyme with systematic name menth-8-ene-1,2-diol:NAD+ oxidoreductase.[1] This enzyme catalyses the following chemical reaction

menth-8-ene-1,2-diol + NAD+ 1-hydroxymenth-8-en-2-one + NADH + H+ (general reaction)
(1) (1S,2S,4R)-menth-8-ene-1,2-diol + NAD+ (1S,4R)-1-hydroxymenth-8-en-2-one + NADH + H+
(2) (1R,2R,4S)-menth-8-ene-1,2-diol + NAD+ (1R,4S)-1-hydroxymenth-8-en-2-one + NADH + H+

While the enzyme from the Gram-positive bacterium Rhodococcus erythropolis DCL14 can use both (1S,2S,4R)- and (1R,2R,4S)-menth-8-ene-1,2-diol as substrate, activity is higher with (1S,2S,4R)-menth-8-ene-1,2-diol as substrate.

References

  1. ↑ van der Werf, M.J.; Swarts, H.J.; de Bont, J.A. (1999). "Rhodococcus erythropolis DCL14 contains a novel degradation pathway for limonene". Appl. Environ. Microbiol. 65 (5): 2092–2102. PMC 91303. PMID 10224006.
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