| Country |
City |
IATA |
ICAO |
Airport |
Notes |
| Argentina | Buenos Aires | EZE | SAEZ | Ministro Pistarini International Airport | Hub for LATAM Argentina |
| Argentina | Buenos Aires | AEP | SABE | Aeroparque Jorge Newbery | Hub for LATAM Argentina |
| Argentina | Córdoba | COR | SACO | Ingeniero Ambrosio Taravella International Airport | |
| Argentina | Mendoza | MDZ | SAME | El Plumerillo International Airport | |
| Argentina | Salta | SLA | SASA | Martín Miguel de Güemes International Airport | Seasonal |
| Argentina | San Juan | UAQ | SANU | Domingo Faustino Sarmiento Airport | |
| Argentina | Rio Gallegos | RGL | SAWG | Piloto Civil Norberto Fernández International Airport | |
| Argentina | Ushuaia | USH | SAWH | Ushuaia – Malvinas Argentinas International Airport | |
| Australia | Melbourne | MEL | YMML | Melbourne Airport | [1] |
| Australia | Sydney | SYD | YSSY | Sydney Airport | via Auckland |
| Bolivia | La Paz | LPB | SLLP | El Alto International Airport | |
| Bolivia | Santa Cruz de la Sierra | VVI | SLVR | Viru Viru International Airport | |
| Brazil | Brasília | BSB | SBBR | Brasília International Airport | Terminated |
| Brazil | Florianópolis | FLN | SBFL | Hercílio Luz International Airport | Seasonal |
| Brazil | Porto Alegre | POA | SBPA | Salgado Filho International Airport | Begins 15 January 2019 |
| Brazil | Rio de Janeiro | GIG | SBGL | Rio de Janeiro–Galeão International Airport | |
| Brazil | Salvador de Bahia | SSA | SBSV | Deputado Luís Eduardo Magalhães International Airport | Terminated |
| Brazil | São Paulo | GRU | SBGR | São Paulo–Guarulhos International Airport | |
| Canada | Toronto | YYZ | CYYZ | Toronto Pearson International Airport | Terminated |
| Chile | Antofagasta | ANF | SCFA | Andrés Sabella Gálvez International Airport | |
| Chile | Arica | ARI | SCAR | Chacalluta International Airport | |
| Chile | Balmaceda | BBA | SCBA | Balmaceda Airport | |
| Chile | Calama | CJC | SCCF | El Loa Airport | |
| Chile | Castro | MHC | SCPQ | Mocopulli Airport | |
| Chile | Concepción | CCP | SCIE | Carriel Sur International Airport | |
| Chile | Copiapó | CPO | SCAT | Desierto de Atacama Airport | |
| Chile | Easter Island | IPC | SCIP | Mataveri International Airport | |
| Chile | El Salvador | ESR | SCES | Ricardo García Posada Airport | Terminated |
| Chile | Iquique | IQQ | SCDA | Diego Aracena International Airport | |
| Chile | La Serena | LSC | SCSE | La Florida Airport | |
| Chile | Llico | — | SCLI | Torca Airport | Terminated |
| Chile | Osorno | ZOS | SCJO | Cañal Bajo Carlos Hott Siebert Airport | |
| Chile | Ovalle | — | SCAD | Ovalle Airport | Terminated |
| Chile | Palena | WAP | SCAP | Alto Palena Airfield | Terminated |
| Chile | Porvenir | WPR | SCFM | Capitán Fuentes Martínez Airport | Terminated |
| Chile | Puerto Montt | PMC | SCTE | El Tepual Airport | |
| Chile | Puerto Williams | WPU | SCGZ | Guardiamarina Zañartu Airport | Terminated |
| Chile | Punta Arenas | PUQ | SCCI | Presidente Carlos Ibáñez del Campo International Airport | |
| Chile | Santiago | SCL | SCEL | Comodoro Arturo Merino Benítez International Airport | Hub for LATAM Chile |
| Chile | Temuco | ZCO | SCTC | La Araucanía International Airport | |
| Chile | Valdivia | ZAL | SCVD | Pichoy Airport | |
| Chile | Vallenar | VLR | SCLL | Vallenar Airport | Terminated |
| Colombia | Bogotá | BOG | SKBO | El Dorado International Airport | Hub for LATAM Colombia |
| Colombia | Cartagena | CTG | SKCG | Rafael Núñez International Airport | Terminated |
| Dominican Republic | Punta Cana | PUJ | MDPC | Punta Cana International Airport | |
| Ecuador | Guayaquil | GYE | SEGU | José Joaquín de Olmedo International Airport | Hub for LATAM Ecuador |
| Ecuador | Quito | UIO | SEQM | Mariscal Sucre International Airport | Hub for LATAM Ecuador |
| Falkland Islands | Stanley | MPN | EGYP | RAF Mount Pleasant | |
| France | Paris | CDG | LFPG | Charles de Gaulle Airport | Terminated |
| French Polynesia, France | Papeete | PPT | NTAA | Fa'a'ā International Airport | via Mataveri |
| Germany | Frankfurt | FRA | EDDF | Frankfurt Airport | via Madrid |
| Israel | Tel Aviv | TLV | LLBG | Ben Gurion International Airport | |
| Italy | Milan | MXP | LIRF | Milan–Malpensa Airport | Terminated |
| Jamaica | Montego Bay | MBJ | MKJS | Sangster International Airport | Terminated |
| Mexico | Cancún | CUN | MMUN | Cancún International Airport | |
| Mexico | Mexico City | MEX | MMMX | Mexico City International Airport | |
| New Zealand | Auckland | AKL | NZAA | Auckland Airport | |
| Panama | Panama City | PTY | MPTO | Tocumen International Airport | Terminated |
| Paraguay | Asunción | ASU | SGAS | Silvio Pettirossi International Airport | |
| Peru | Lima | LIM | SPIM | Jorge Chávez International Airport | Hub for LATAM Perú |
| Spain | Barcelona | BCN | LEBL | Barcelona–El Prat Airport | |
| Spain | Madrid | MAD | LEMD | Adolfo Suárez Madrid–Barajas Airport | |
| United States | Boston | BOS | KBOS | Logan International Airport | |
| United States | Los Angeles | LAX | KLAX | Los Angeles International Airport | |
| United States | Orlando | MCO | KMCO | Orlando International Airport | |
| United States | Miami | MIA | KMIA | Miami International Airport | |
| United States | New York City | JFK | KJFK | John F. Kennedy International Airport | |
| United States | San Francisco | SFO | KSFO | San Francisco International Airport | Terminated |
| United States | Washington, D.C. | IAD | KIAD | Washington Dulles International Airport | |
| Uruguay | Montevideo | MVD | SUMU | Carrasco International Airport | |
| Uruguay | Punta del Este | PDP | SULS | Capitán de Corbeta Carlos A. Curbelo International Airport | Seasonal |
| Venezuela | Caracas | CCS | SVMI | Simón Bolívar International Airport | Terminated |
|
