Hydrocortisone buteprate

Hydrocortisone buteprate
Clinical data
Synonyms	Hydrocortisone 17-butyrate 21-propionate
AHFS/Drugs.com	Monograph
Pregnancy; category	US: C (Risk not ruled out) ;
ATC code	D07AB11 (WHO) ;
Legal status
Legal status	US: OTC ;
Identifiers
	IUPAC name (11β)-11-hydroxy-3,20-dioxo-21-(propionyloxy)pregn-4-en-17-yl butyrate;
CAS Number	72590-77-3 ;
PubChem CID	636398;
ChemSpider	552186 ;
ECHA InfoCard	100.069.730
Chemical and physical data
Formula	C28H40O7
Molar mass	488.613 g/mol
3D model (JSmol)	Interactive image;
	SMILES CCCC(=O)O[C@@]1(CC[C@@H]2[C@@]1(C[C@@H]([C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)O)C)C(=O)COC(=O)CC;
	InChI InChI=1S/C28H40O7/c1-5-7-24(33)35-28(22(31)16-34-23(32)6-2)13-11-20-19-9-8-17-14-18(29)10-12-26(17,3)25(19)21(30)15-27(20,28)4/h14,19-21,25,30H,5-13,15-16H2,1-4H3/t19-,20-,21-,25+,26-,27-,28-/m0/s1 ; Key:FOGXJPFPZOHSQS-AYVLZSQQSA-N ;
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Hydrocortisone buteprate is a topical steroid.^[1]^[2] It is an ester of hydrocortisone (cortisol) with butyric acid and propionic acid.

References

↑ Drugs.com: Hydrocortisone Buteprate topical
↑ Sears, H. W.; Bailer, J. W.; Yeadon, A. (1997). "Efficacy and safety of hydrocortisone buteprate 0.1% cream in patients with atopic dermatitis". Clinical therapeutics. 19 (4): 710–719. doi:10.1016/s0149-2918(97)80095-1. PMID 9377615.

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