HLA-B50

major histocompatibility complex (human), class I, B50
Alleles B*5001, B*5002,
Structure (See HLA-B)
Symbol(s) HLA-B
EBI-HLA B*5001
B*5002
Locus chr.6 6p21.31

HLA-B50 (B50) is an HLA-B serotype. B50 is a split antigen from the B21 broad antigen, the sister serotype B49.[1] The serotype identifies the more common HLA-B*50 gene products.[2] (For terminology help see: HLA-serotype tutorial)

Serotype

B50 and B21 serotype recognition of some more common HLA B*50 alleles[3]
B*50B50 B21Sample
allele%%size (N)
50018531700

The B*5002 by serotype definition is a B45 serotype.[4]

Allele distribution

HLA B*5001 frequencies
freq
ref.Population(%)
[5]Saudi Arabia Guraiat and Hail17.3
[5]Tunisia10.0
[5]Israel Arab Druse8.5
[5]Morocco Nador Metalsa (Berber)7.3
[5]Tunisia Tunis6.3
[5]Israel Ashkenazi and Non Ashkenazi Jews5.5
[5]Azores Terceira Island5.1
[5]Georgia Svaneti Svans3.8
[5]India North Delhi3.8
[5]Italy Bergamo3.6
[5]Georgia Tibilisi Kurds3.4
[5]Italy North (1)3.3
[5]Brazil Belo Horizonte3.2
[5]Madeira3.2
[5]Italy North Pavia3.1
[5]Portugal South3.1
[5]Oman3.0
[5]Georgia Tibilisi Georgians2.8
[5]Bulgaria2.7
[5]Azores Santa Maria and Sao Miguel2.6
[5]Spain Eastern Andalusia Gipsy2.5
[5]Sudanese2.5
[5]Czech Republic2.4
[5]Spain Eastern Andalusia2.4
[5]Spain Mallorca and Menorca2.2
[5]Burkina Faso Fulani2.0
[5]China Inner Mongolia2.0
[5]China North Han1.9
[5]India North Hindus1.9
[5]China Qinghai Hui1.8
[5]Jordan Amman1.7
[5]Russia Tuva (2)1.7
[5]Spain Catalonia Girona1.7
[5]Senegal Niokholo Mandenka1.6
[5]Guinea Bissau1.5
[5]India New Delhi1.5
[5]Croatia1.3
[5]Cuban Mulatto1.2
[5]France South East1.2
[5]Burkina Faso Rimaibe1.1
[5]Mali Bandiagara1.1
[5]Belgium1.0
[5]Ireland Northern1.0
[5]Ireland South1.0
[5]Italy Sardinia pop31.0
[5]South Africa Natal Tamil1.0
B*5002
[5]Morocco Nador Metalsa (Berber)4.3
[5]Portugal North1.1
[5]Portugal South1.0
[5]Madeira0.8
[5]Tunisia Tunis0.6

References

  1. ↑ Hildebrand WH, Madrigal JA, Belich MP, et al. (1992). "Serologic cross-reactivities poorly reflect allelic relationships in the HLA-B12 and HLA-B21 groups. Dominant epitopes of the alpha 2 helix". J. Immunol. 149 (11): 3563–8. PMID 1385528.
  2. ↑ Marsh SG, Albert ED, Bodmer WF, et al. (2005). "Nomenclature for factors of the HLA system, 2004". Tissue Antigens. 65 (4): 301–69. doi:10.1111/j.1399-0039.2005.00379.x. PMID 15787720.
  3. ↑ derived from IMGT/HLA
  4. ↑ Balas A, Santos S, García-Sánchez F, Lillo R, Merino L, Vicario JL (1998). "Characterization and distribution of HLA-B*5002 in a Spanish population sample". Tissue Antigens. 52 (2): 183–6. doi:10.1111/j.1399-0039.1998.tb02283.x. PMID 9756408.
  5. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660. External link in |title= (help)
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