HLA-B49




major histocompatibility complex (human), class I, B49
Alleles	B4901, B4902, B*4903
Structure (See HLA-B)
Symbol(s)	HLA-B
EBI-HLA	B*4901
	B*4902
	B*4903
Locus	chr.6 6p21.31

HLA-B49 (B49) is an HLA-B serotype. B49 is a split antigen from the B21 broad antigen, the sister serotype B50.^[1] The serotype identifies the more common HLA-B*50 gene products.^[2] (For terminology help see: HLA-serotype tutorial)

Serotype

B49 and B21 serotype recognition of some more common HLA B*49 alleles^[3]
B*49	B49	B21	Sample
allele	%	%	size (N)
4901	94	1	3002

Allele distribution

**HLA B*4901 frequencies**
		freq
ref.	Population	(%)
^[4]	Portugal North	8.7
^[4]	Spain Basque Gipuzkoa Province	6.1
^[4]	Madeira	5.9
^[4]	Cameroon Yaounde	5.4
^[4]	Morocco Nador Metalsa (Berber)	5.1
^[4]	Kenya Nandi	4.6
^[4]	Sudanese	4.3
^[4]	Portugal South	4.1
^[4]	Tunisia Tunis	4.0
^[4]	India Jalpaiguri Toto	3.8
^[4]	Senegal Niokholo Mandenka	3.7
^[4]	Uganda Kampala	3.7
^[4]	Spain Eastern Andalusia	3.5
^[4]	Tunisia	3.5
^[4]	Georgia Tibilisi Kurds	3.4
^[4]	Spain Catalonia Girona	3.4
^[4]	Italy North (1)	3.3
^[4]	Cameroon Beti	3.2
^[4]	Israel Ashkenazi and Non Ashkenazi Jews	3.2
^[4]	Guinea Bissau	3.1
^[4]	France South East	2.7
^[4]	Israel Arab Druse	2.5
^[4]	Mali Bandiagara	2.5
^[4]	Jordan Amman	2.4
^[4]	Tunisia Ghannouch	2.4
^[4]	Georgia Tibilisi Georgians	2.3
^[4]	Saudi Arabia Guraiat and Hail	2.2
^[4]	Cameroon Bamileke	1.9
^[4]	Czech Republic	1.9
^[4]	Georgia Svaneti Svans	1.9
^[4]	Macedonia (4)	1.9
^[4]	Bulgaria	1.8
^[4]	Romanian	1.6
^[4]	Italy Bergamo	1.1
^[4]	Zambia Lusaka	1.1
^[4]	Belgium	1.0
^[4]	China North Han	1.0
^[4]	India Andhra Pradesh Golla	1.0
^[4]	Ireland Northern	1.0
^[4]	South African Natal Zulu	1.0

References

↑ Hildebrand WH, Madrigal JA, Belich MP, et al. (1992). "Serologic cross-reactivities poorly reflect allelic relationships in the HLA-B12 and HLA-B21 groups. Dominant epitopes of the alpha 2 helix". J. Immunol. 149 (11): 3563–8. PMID 1385528.
↑ Marsh SG, Albert ED, Bodmer WF, et al. (2005). "Nomenclature for factors of the HLA system, 2004". Tissue Antigens. 65 (4): 301–69. doi:10.1111/j.1399-0039.2005.00379.x. PMID 15787720.
↑ derived from IMGT/HLA
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660. External link in |title= (help)

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[pmid1385528-1] Hildebrand WH, Madrigal JA, Belich MP, et al. (1992). "Serologic cross-reactivities poorly reflect allelic relationships in the HLA-B12 and HLA-B21 groups. Dominant epitopes of the alpha 2 helix". J. Immunol. 149 (11): 3563–8. PMID 1385528.

[pmid15787720-2] Marsh SG, Albert ED, Bodmer WF, et al. (2005). "Nomenclature for factors of the HLA system, 2004". Tissue Antigens. 65 (4): 301–69. doi:10.1111/j.1399-0039.2005.00379.x. PMID 15787720.

[3] rived from IMGT/HLA

[pmid12753660-4] 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660. External link in |title= (help)