Gregory Hannon

Greg Hannon
FRS FMedSci
Born Gregory James Hannon[1]
1964 (age 53–54)[2]
Alma mater Case Western Reserve University (BA, PhD)[3]
Awards EMBO Member (2018)[4]
Royal Society Wolfson Research Merit Award (2015)[5]
Scientific career
Fields
Institutions University of Cambridge
New York Genome Center
Cold Spring Harbor Laboratory
Howard Hughes Medical Institute[7]
Thesis Trans-splicing of nematode pre-messenger RNA (1992)
Doctoral advisor Timothy W. Nilsen[8]
Notable students Lin He (postdoc)
Influences Simon Tavaré[9]
Shankar Balasubramanian[9]
Website hannonlab.org

Gregory James Hannon FRS FMedSci[10] is a professor of molecular cancer biology and director of the Cancer Research UK Cambridge Research Institute at the University of Cambridge.[3] He is a Fellow of Trinity College, Cambridge[11][12] while also serving as a director of cancer genomics at the New York Genome Center[13] and an adjunct professor at Cold Spring Harbor Laboratory.[14]

Hannon is known for his contributions to small RNA biology, cancer biology, and mammalian genomics.[10][6][15][16] He has a history in discovery of oncogenes, beginning with work that led to the identification of CDK inhibitors and their links to cancer.[10] More recently, his work has focused on small RNA biology, which led to an understanding of the biochemical mechanisms and biological functions of RNA interference (RNAi).[17][18][10] He has developed widely used tools and strategies for manipulation of gene expression in mammalian cells and animals and has generated genome-wide short hairpin RNA (shRNA) libraries that are available to the cancer community and was among the first to demonstrate roles for microRNAs in cancer.[10][19] His laboratory also discovered the piwi-interacting RNA (piRNA) pathway and linked this to transposon repression and the protection of germ cell genomes.[10] His innovations include the development of selective re-sequencing strategies, broadly termed exome capture.[10]

References

  1. ↑ Greg Hannon's Entry at ORCID
  2. ↑ Gregory Hannon at Library of Congress Authorities
  3. 1 2 "Greg Hannon – Hannon Laboratory". hannonlab.org. Retrieved 20 June 2018.
  4. ↑ "Find people in the EMBO Communities". people.embo.org. Retrieved 20 June 2018.
  5. ↑ "Gregory Hannon". royalsociety.org. Retrieved 20 June 2018.
  6. 1 2 3 4 5 6 Gregory Hannon publications indexed by Google Scholar Edit this at Wikidata
  7. ↑ "Gregory J. Hannon, PhD - HHMI.org".
  8. ↑ Hannon, Gregory James (1992). Trans-splicing of nematode pre-messenger RNA. proquest.com (PhD thesis). Case Western Reserve University. OCLC 29529734.
  9. 1 2 CRUK, Research at (16 July 2015). "Raring to go with RNAi research".
  10. 1 2 3 4 5 6 7 Anon (2018). "Professor Gregory Hannon FRS". royalsociety.org. London: Royal Society. One or more of the preceding sentences incorporates text from the royalsociety.org website where:
    “All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License.” --"{title}". Archived from the original on 2016-11-11. Retrieved 2018-06-20.
  11. ↑ "Professor Greg Hannon leads £20 million Grand Challenge project to build 3D cancer tumour".
  12. ↑ "Professor Greg Hannon appointed new Director of Cancer Research UK Cambridge Institute".
  13. ↑ "Hannon Lab @ New York Genome Center". nygenome.org. Retrieved 20 June 2018.
  14. ↑ "Hannon Laboratory @CSHL". hannonlab.cshl.edu.
  15. ↑ Gregory Hannon publications indexed by the Scopus bibliographic database. (subscription required)
  16. ↑ Gregory Hannon publications from Europe PubMed Central
  17. ↑ Hannon, Gregory J. (2002). "RNA interference". Nature. 418 (6894): 244–251. doi:10.1038/418244a. ISSN 0028-0836. PMID 12110901.
  18. ↑ Bernstein, Emily; Caudy, Amy A.; Hammond, Scott M.; Hannon, Gregory J. (2001). "Role for a bidentate ribonuclease in the initiation step of RNA interference". Nature. 409 (6818): 363–366. doi:10.1038/35053110. ISSN 0028-0836. PMID 11201747.
  19. ↑ Murchison, Elizabeth P.; Hannon, Gregory J. (2004). "miRNAs on the move: miRNA biogenesis and the RNAi machinery". Current Opinion in Cell Biology. 16 (3): 223–9. doi:10.1016/j.ceb.2004.04.003. PMID 15145345.

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