G.I. Joe: Renegades

A team of five soldiers—Duke, Rip Cord, Tunnel Rat, Roadblock and Scarlett—are sent to investigate Cobra Pharmaceuticals. They discover Cobra's new top secret weapon, Bio-Vipers, but are discovered and are forced to blow the facility to save themselves.

After surviving the Cobra factory explosion, the team are framed for the explosion at Cobra Pharmaceuticals and are now known as the "Renegades" by the media. The team then goes after a surviving Bio Viper that is heading to Springfield. While Baroness and Doctor Mindbender oversee the "quarantine," General Abernathy sends Flint to get Lady Jaye to help him bring in Duke's team.

Posing as a preacher that helps veterans, Scrap-Iron kidnaps Tunnel Rat and uses him to test a weaponized "exo-armor" suit for James McCullen and his M.A.R.S. Industries. He meets Ralph Pulaski (a.k.a. Steeler) in another suit and they must battle each other to survive. Roadblock then attempts a rescue by allowing himself to be captured, but he is forced into an exo-suit as well. Now the rest of the Joes have to save him too.

The Joes make a pit stop in a small town in Kansas and quickly find themselves tangling with the Dreadnoks, their leader Zartan, and a cowardly local sheriff. Now they must race against time to help the locals free themselves from the Dreadnoks reign of terror, give the sheriff back his courage, put the whole gang behind bars, and get out of dodge before Flint arrives to arrest them.

The Baroness contacts mercenary Major Bludd to track down and assassinate a target—a former Cobra employee and internet blogger—who they believed stole one of their data scanners.

The Joes take refuge at Snake Eye's dojo where they train with him and meet his first apprentice Jinx. They also learn about his connection to Storm Shadow and their connected past in the Arashikage ninja clan.

Duke is wrongfully imprisoned when he gets caught up in a chop shop while looking for a replacement part for their vehicle. The rest of G.I. Joe must break him out of prison by having Roadblock get arrested. They soon discover that the prison warden is making prisoners fight each other for his amusement. Now the Joes must get Duke and Roadblock out and expose the illegal activities in the prison.

Adam DeCobray hires James McCullen of M.A.R.S. Industries to work on a project to combine Dr. Mindbender's Bio-Vipers with his failed exo-armor suits. Meanwhile, the Joes infiltrate a Cobra stronghold after receiving information of DeCobray's plans from who they thought was Breaker's masked whistleblower. During the attempt, Mindbender reveals a deadly secret leading DeCobray to reveal himself as Cobra Commander. James McCullen becomes a "Destro" (estranged/alienated one) as he is forced to wear an iron mask as a symbol of his attempted betrayal and a mark of his servitude to Cobra.

When the town of Green Ridge, is issued a court order to halt the construction of a dam built by Cobra Industries, Baroness and Doctor Mindbender send Firefly to burn this former resort town to the ground, leaving it up to G.I. Joe and a local firefighter to stop him.

Duke heads home to Missouri to protect his family from a Cobra attack while the Joes infiltrate Cobra's Christmas party in Washington D.C. to find Adam DeCobray (a.k.a. Cobra Commander). Also the origins of Duke's adolescent past with Flint during a high school football state championship game are revealed.

With the Joes in Flint's military custody, the Baroness tries to regain control of the computer hard drive that holds Cobra's secrets from the military train that they are on. The Joes identities are compromised and they're now called the "Springfield Four" by the media. After losing a battle with Snake Eyes on top a moving train, Storm Shadow approaches the Baroness to form an alliance with Cobra.

Disguising themselves as spiritual healers, Tomax and Xamot entrance the Joes and trap them in their cult-like commune called the Brothers of Light after they help Sister Leia, one of their disciples escape. Meanwhile, Doctor Mindbender is seeking a psychic in order to learn the twins' secret and use their psych abilities to adapt a control system enhancement for his Bio-Vipers.

Introducing Characters: Tomax and Xamot, Crimson Guard

Flint and Lady Jaye get Zartan out of prison to help them track down the Joes. Meanwhile, the Baroness tries to transport a camouflage suit—technology that can duplicate anyone's appearance—to Cobra Commander. Zartan steals the suit. The Joes and the Falcons along with warrant officer/helicopter pilot William "Wild Bill" Hardy must capture Zartan and retrieve the camo suit before it ends up in the hands of Cobra.

When Dr. Mindbender creates prototype "Shadow-Vipers", these synthetic doppelgangers controlled by Storm Shadow's mind follow the Joes to Canada, where they are hiding out with Snow Job, Tunnel Rat's old army arctic tropper buddy. But Snow Job doesn't give the team the warm welcome in the cold weather they expected. Meanwhile Snake Eyes rescues a timber wolf caught in a hunter's trap and winds up needing to be rescued himself.

A sea captain, Hector Delgado, helps the Joes transport a canister containing a prototype Techno-Viper taken from Cobra's lab in the arctic to Washington D.C. in hopes to give it to General Abernathy as evidence that would expose the illegal activities of Cobra Industries. But things go wrong aboard his ship, Courtney along the journey.

Introducing Characters: Shipwreck, Cover Girl (in a poster as Courtney Kreiger), USS Flagg, Techno-Viper

Tracing the prototype Techno-Viper's signal following its defeat, the Joes end up in Scotland. While there, the Joes become trapped inside Destro’s castle during a recon mission investigating a Cobra weapon called the Bio-Dag, a missile that dispenses Bio-Vipers on the masses.

The Joes plan to crash a communications summit held by Baroness at the Cisarovna Chateau where they uncover a mind control scheme involving Cobra Industries' "Black Adder" invention. This cellular device can take control of their competition by cerebral manipulation using Doctor Mindbender's mind-control technology siphoned from Tomax and Xamot's psychic ability. However, the Joes soon discover that someone else has infiltrated the estate with an axe to grind against the Cisarovna family and their reign.

Introducing Characters: Red Star (of the Oktober Guard)

The Joes uncover a deadly virus called the Anaconda Strain (a mammalian virus engineered from reptile DNA) while searching for a missing biochemist in Mexico. They also learn of Cobra's plan to profit from the sale of its antidote.

The Joes raid Cobra's medical facility to search for "Patient X" (who was previously used as a test subject for the creation of the Anaconda Strain virus) and any other information that would help them prevent an outbreak. They soon discover that Patient X is actually an amnesiac Ripcord and help to regain his memory unaware that he has been turned into a Bio-Viper/human hybrid by Doctor Mindbender. Meanwhile, Cobra Commander is told by Doctor Mindbender that this is a good opportunity to track the Joes' location and movements since their interference is now out in the open.

Doctor Mindbender's attempt to create another human/Bio-Viper hybrid appeared to be a failure at first until it ends up reassembling in the New York City sewer system. When Duke, Roadblock, and Ripcord go along with Tunnel Rat to his hometown of Brooklyn to find a missing child named Reggie, they encounter the Sewer Viper being pursued by Doctor Mindbender and some Bio-Vipers on Cobra Commander's orders. Doctor Mindbender also tries to reclaim Ripcord back as Patient X at the same time. In the end, the hybrid removes the control chip allowing Ripcord control of his Bio-Viper mutation and Tunnel Rat visits his parents, going around the back to avoid MPs in front.

Flint hires Corporal Hershel Dalton (aka: Heavy Duty) to apprehend his estranged cousin Roadblock while he and the team are in his hometown of Biloxi, Mississippi for their grandpa's WWII memorial. Meanwhile, Major Bludd resurfaces and plans his revenge on the Joes for the eye injury he suffered in their last showdown.

After a experience with what appeared to be the ghost of her father Professor Patrick O'Hara, Scarlett and the Joes go to her hometown of Atlanta, Georgia where she visits her vacant family home. She learns from footage recovered by Snake Eyes that her father invented the Molecular Assembler Scrambler Sender (a.k.a. MASS Device) for Cobra Industries to use for teleporting troops into battle. Meanwhile, Baroness commands the Bio-Vipers into attacking the Joes when she learns that the stone in Scarlett's locket plays a part in Cobra Commander's plot to use the MASS Device. The reason for Snake Eyes wearing a mask is also revealed.

Introducing Characters: Professor Patrick O'Hara (Scarlett's father)

As Scarlett's locket is in Baroness and Doctor Mindbender's possession, the Joes end up taking the fight to Cobra Industries by infiltrating their stronghold in order to stop them from finishing the MASS device. Later, the Joes arrive in Washington D.C. in Destro's High Speed Sentry (a.k.a. HISS tank) and are surrounded by General Abernathy and the Falcons. Scarlett shows them the proof from the lab that they need to clear their names. In the end, Cobra Industries' secrets are revealed and Cobra Commander declares war on the Joes.

Trivia #1: The original broadcast included a trailer segment showcasing the 1980s Sunbow cartoon version of Duke stating the Renegades reality was "just a dream", specifically separating the two interpretations. The other counterparts of the Renegades crew refute the Renegades reality, laughing at the description Real American Duke tells them.

Trivia #2: The H.I.S.S. tank from the old series was introduced along with Destro's signature outfit.