Formate dehydrogenase (acceptor)

Formate dehydrogenase (acceptor)
Identifiers
EC number 1.1.99.33
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Formate dehydrogenase (acceptor) (EC 1.1.99.33, FDHH, FDH-H, FDH-O, formate dehydrogenase H, formate dehydrogenase O) is an enzyme with systematic name formate:acceptor oxidoreductase.[1][2][3] This enzyme catalyses the following chemical reaction

formate + acceptor CO2 + reduced acceptor

Formate dehydrogenase H is a cytoplasmic enzyme that oxidizes formate without oxygen transfer] transferring electrons to a hydrogenase.

References

  1. ↑ Axley MJ, Grahame DA, Stadtman TC (October 1990). "Escherichia coli formate-hydrogen lyase. Purification and properties of the selenium-dependent formate dehydrogenase component". The Journal of Biological Chemistry. 265 (30): 18213–8. PMID 2211698.
  2. ↑ Gladyshev VN, Boyington JC, Khangulov SV, Grahame DA, Stadtman TC, Sun PD (April 1996). "Characterization of crystalline formate dehydrogenase H from Escherichia coli. Stabilization, EPR spectroscopy, and preliminary crystallographic analysis". The Journal of Biological Chemistry. 271 (14): 8095–100. PMID 8626495.
  3. ↑ Khangulov SV, Gladyshev VN, Dismukes GC, Stadtman TC (March 1998). "Selenium-containing formate dehydrogenase H from Escherichia coli: a molybdopterin enzyme that catalyzes formate oxidation without oxygen transfer". Biochemistry. 37 (10): 3518–28. doi:10.1021/bi972177k. PMID 9521673.
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