DNA oxidative demethylase
| DNA oxidative demethylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.14.11.33 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
DNA oxidative demethylase (EC 1.14.11.33, alkylated DNA repair protein, alpha-ketoglutarate-dependent dioxygenase ABH1, alkB (gene)) is an enzyme with systematic name methyl DNA-base, 2-oxoglutarate:oxygen oxidoreductase (formaldehyde-forming).[1][2][3] This enzyme catalyses the following chemical reaction
- DNA-base-CH3 + 2-oxoglutarate + O2 DNA-base + formaldehyde + succinate + CO2
DNA oxidative demethylase contains iron; activity is somewhat stimulated by ascorbate.
References
- ↑ Falnes, P.O.; Johansen, R.F.; Seeberg, E. (2002). "AlkB-mediated oxidative demethylation reverses DNA damage in Escherichia coli". Nature. 419 (6903): 178–182. Bibcode:2002Natur.419..178F. doi:10.1038/nature01048. PMID 12226668.
- ↑ Yi, C.; Yang, C.G.; He, C. (2009). "A non-heme iron-mediated chemical demethylation in DNA and RNA". Acc. Chem. Res. 42 (4): 519–529. doi:10.1021/ar800178j. PMC 2920458. PMID 19852088.
- ↑ Yi, C.; Jia, G.; Hou, G.; Dai, Q.; Zhang, W.; Zheng, G.; Jian, X.; Yang, C.G.; Cui, Q.; He, C. (2010). "Iron-catalysed oxidation intermediates captured in a DNA repair dioxygenase". Nature. 468 (7321): 330–333. Bibcode:2010Natur.468..330Y. doi:10.1038/nature09497. PMC 3058853. PMID 21068844.
External links
- DNA+oxidative+demethylase at the US National Library of Medicine Medical Subject Headings (MeSH)
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