Cathepsin O

CTSO
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCTSO, CTSO1, cathepsin O
External IDsOMIM: 600550 MGI: 2139628 HomoloGene: 1020 GeneCards: CTSO
Gene location (Human)
Chr.Chromosome 4 (human)[1]
Band4q32.1Start155,924,118 bp[1]
End155,953,917 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

1519

229445

Ensembl

ENSG00000263238
ENSG00000256043

ENSMUSG00000028015

UniProt

P43234

Q8BM88

RefSeq (mRNA)

NM_001334

NM_177662

RefSeq (protein)

NP_001325

NP_808330

Location (UCSC)Chr 4: 155.92 – 155.95 MbChr 3: 81.93 – 81.96 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cathepsin O is an enzyme that in humans is encoded by the CTSO gene.[5][6]

Function

Cathepsin O is a cysteine protease and a member of the cathepsin family and papain superfamily. This proteolytic enzyme is involved in cellular protein degradation and turnover. The recombinant form of this enzyme was shown to degrade synthetic peptides typically used as substrates for cysteine proteinases and its proteolytic activity was abolished by an inhibitor of cyteine proteinase.[6]

References

  1. 1 2 3 ENSG00000256043 GRCh38: Ensembl release 89: ENSG00000263238, ENSG00000256043 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028015 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Santamaría I, Pendás AM, Velasco G, López-Otín C (October 1998). "Genomic structure and chromosomal localization of the human cathepsin O gene (CTSO)". Genomics. 53 (2): 231–4. doi:10.1006/geno.1997.5180. PMID 9790772.
  6. 1 2 "Entrez Gene: cathepsin O".

Further reading

  • Shi GP, Chapman HA, Bhairi SM, et al. (1995). "Molecular cloning of human cathepsin O, a novel endoproteinase and homologue of rabbit OC2". FEBS Lett. 357 (2): 129–34. doi:10.1016/0014-5793(94)01349-6. PMID 7805878.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Velasco G, Ferrando AA, Puente XS, et al. (1994). "Human cathepsin O. Molecular cloning from a breast carcinoma, production of the active enzyme in Escherichia coli, and expression analysis in human tissues". J. Biol. Chem. 269 (43): 27136–42. PMID 7929457.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Barbe L, Lundberg E, Oksvold P, et al. (2008). "Toward a confocal subcellular atlas of the human proteome". Mol. Cell. Proteomics. 7 (3): 499–508. doi:10.1074/mcp.M700325-MCP200. PMID 18029348.
  • The MEROPS online database for peptidases and their inhibitors: C01.035

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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