CDH16

CDH16
Identifiers
AliasesCDH16, cadherin 16
External IDsMGI: 106671 HomoloGene: 2997 GeneCards: CDH16
Gene location (Human)
Chr.Chromosome 16 (human)[1]
Band16q22.1Start66,908,122 bp[1]
End66,918,984 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

1014

12556

Ensembl

ENSG00000166589

ENSMUSG00000031881

UniProt

O75309

O88338

RefSeq (mRNA)

NM_001204744
NM_001204745
NM_001204746
NM_004062

NM_001252627
NM_001252628
NM_007663

RefSeq (protein)

NP_001191673
NP_001191674
NP_001191675
NP_004053

NP_001239556
NP_001239557
NP_031689

Location (UCSC)Chr 16: 66.91 – 66.92 MbChr 8: 104.6 – 104.62 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cadherin-16 is a protein that in humans is encoded by the CDH16 gene.[5][6][7]

This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Mapped to a previously identified cluster of cadherin genes on chromosome 16q22.1, the gene localizes with superfamily members CDH1, CDH3, CDH5, CDH8 and CDH11. The protein consists of an extracellular domain containing 6 cadherin domains, a transmembrane region and a truncated cytoplasmic domain but lacks the prosequence and tripeptide HAV adhesion recognition sequence typical of most classical cadherins. Expression is exclusively in the kidney, where the protein functions as the principal mediator of homotypic cellular recognition, playing a role in the morphogenic direction of tissue development.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000166589 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031881 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Thomson RB, Ward DC, Quaggin SE, Igarashi P, Muckler ZE, Aronson PS (Oct 1998). "cDNA cloning and chromosomal localization of the human and mouse isoforms of Ksp-cadherin". Genomics. 51 (3): 445–51. doi:10.1006/geno.1998.5402. PMID 9721215.
  6. ↑ Thomson RB, Igarashi P, Biemesderfer D, Kim R, Abu-Alfa A, Soleimani M, Aronson PS (Aug 1995). "Isolation and cDNA cloning of Ksp-cadherin, a novel kidney-specific member of the cadherin multigene family". J Biol Chem. 270 (29): 17594–601. doi:10.1074/jbc.270.29.17594. PMID 7615566.
  7. 1 2 "Entrez Gene: CDH16 cadherin 16, KSP-cadherin".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Thomson RB, Aronson PS (1999). "Immunolocalization of Ksp-cadherin in the adult and developing rabbit kidney". Am. J. Physiol. 277 (1 Pt 2): F146–56. PMID 10409308.
  • Baudry D, Jeanpierre C (2000). "Assignment of E-cadherin (CDH1) and KSP-cadherin (CDH16) to chromosome 16q22.1 by radiation hybrid mapping". Cytogenet. Cell Genet. 88 (3–4): 253–4. doi:10.1159/000015531. PMID 10828602.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Thomson RB, Mentone S, Kim R, et al. (2003). "Histopathological analysis of renal cystic epithelia in the Pkd2WS25/- mouse model of ADPKD". Am. J. Physiol. Renal Physiol. 285 (5): F870–80. doi:10.1152/ajprenal.00153.2003. PMID 12851251.
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  • Wendeler MW, Praus M, Jung R, et al. (2004). "Ksp-cadherin is a functional cell-cell adhesion molecule related to LI-cadherin". Exp. Cell Res. 294 (2): 345–55. doi:10.1016/j.yexcr.2003.11.022. PMID 15023525.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Hishikawa K, Marumo T, Miura S, et al. (2005). "Leukemia inhibitory factor induces multi-lineage differentiation of adult stem-like cells in kidney via kidney-specific cadherin 16". Biochem. Biophys. Res. Commun. 328 (1): 288–91. doi:10.1016/j.bbrc.2004.12.167. PMID 15670782.
  • Thedieck C, Kuczyk M, Klingel K, et al. (2005). "Expression of Ksp-cadherin during kidney development and in renal cell carcinoma". Br. J. Cancer. 92 (11): 2010–7. doi:10.1038/sj.bjc.6602597. PMC 2361784. PMID 15886705.
  • Kuehn A, Paner GP, Skinnider BF, et al. (2007). "Expression analysis of kidney-specific cadherin in a wide spectrum of traditional and newly recognized renal epithelial neoplasms: diagnostic and histogenetic implications". Am. J. Surg. Pathol. 31 (10): 1528–33. doi:10.1097/PAS.0b013e318058818c. PMID 17895753.


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