Angiotensin II (medication)

Angiotensin II
Clinical data
Trade names	Giapreza
AHFS/Drugs.com	Professional Drug Facts
Routes of; administration	Intravenous injection
Drug class	Vasoconstrictor
Pharmacokinetic data
Elimination half-life	less than one minute (IV administration)
Identifiers
	IUPAC name L-alpha-aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-L-phenylalanine;
CAS Number	4474-91-3;
PubChem CID	172198;
DrugBank	DB11842;
Chemical and physical data
Formula	C50H71N13O12
Molar mass	1,046.20 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)O)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(=O)O)N;
	InChI InChI=InChI=1S/C50H71N13O12/c1-5-28(4)41(47(72)59-36(23-31-25-54-26-56-31)48(73)63-20-10-14-38(63)45(70)60-37(49(74)75)22-29-11-7-6-8-12-29)62-44(69)35(21-30-15-17-32(64)18-16-30)58-46(71)40(27(2)3)61-43(68)34(13-9-19-55-50(52)53)57-42(67)33(51)24-39(65)66/h6-8,11-12,15-18,25-28,33-38,40-41,64H,5,9-10,13-14,19-24,51H2,1-4H3,(H,54,56)(H,57,67)(H,58,71)(H,59,72)(H,60,70)(H,61,68)(H,62,69)(H,65,66)(H,74,75)(H4,52,53,55)/t28-,33-,34-,35-,36-,37-,38-,40-,41-/m0/s1; Key:CZGUSIXMZVURDU-JZXHSEFVSA-N;

Angiotensin II is a medication that is used to treat hypotension resulting from septic shock. It is a synthetic vasoconstrictor peptide that is identical to human hormone angiotensin II^[1] and is marketed under the brandname Giapreza. The Food and Drug Administration approved the use of Giapreza in December of 2017 to treat low blood pressure resulting from septic shock.^[2]

References

↑ Kaufman MB (March 2018). "Pharmaceutical Approval Update". P & T : a Peer-reviewed Journal for Formulary Management. 43 (3): 141–170. PMID 29491694.
↑ "FDA approves drug to treat dangerously low blood pressure". United States Food and Drug Administration. 21 December 2017.

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