Alkylglycerone phosphate synthase

alkylglycerone-phosphate synthase
Identifiers
EC number 2.5.1.26
CAS number 64060-42-0
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO
alkylglycerone phosphate synthase
Identifiers
Symbol AGPS
Entrez 8540
HUGO 327
OMIM 603051
RefSeq NM_003659
UniProt O00116
Other data
EC number 2.5.1.26
Locus Chr. 2 q31

Alkylglycerone phosphate synthase (EC 2.5.1.26, alkyldihydroxyacetonephosphate synthase, alkyldihydroxyacetone phosphate synthetase, alkyl DHAP synthetase, alkyl-DHAP, dihydroxyacetone-phosphate acyltransferase, DHAP-AT) is an enzyme associated with Type 3 Rhizomelic chondrodysplasia punctata.[1][2] This enzyme catalyses the following chemical reaction

1-acyl-glycerone 3-phosphate + a long-chain alcohol an alkyl-glycerone 3-phosphate + a long-chain acid anion

References

  1. ↑ Brown AJ, Snyder F (August 1982). "Alkyldihydroxyacetone-P synthase. Solubilization, partial purification, new assay method, and evidence for a ping-pong mechanism". The Journal of Biological Chemistry. 257 (15): 8835–9. PMID 7096336.
  2. ↑ Wykle RL, Plantadosi C, Snyder F (May 1972). "The role of acyldihydroxyacetone phosphate, reduced nicotinamide adenine dinucleotide, and reduced nicotinamide adenine dinucleotide phosphate in the biosynthesis of O-alkyl glycerolipids by microsomal enzymes of Ehrlich ascites tumor". The Journal of Biological Chemistry. 247 (9): 2944–8. PMID 4401994.
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