Alcohol dehydrogenase (azurin)

Alcohol dehydrogenase (azurin)
Identifiers
EC number 1.1.9.1
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Alcohol dehydrogenase (azurin) (EC 1.1.9.1, type II quinoprotein alcohol dehydrogenase, quinohaemoprotein ethanol dehydrogenase, QHEDH, ADHIIB) is an enzyme with systematic name alcohol:azurin oxidoreductase.[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction

primary alcohol + azurin aldehyde + reduced azurin

This enzyme is a periplasmic PQQ-containing quinohemoprotein.

References

  1. ↑ Groen, B.W.; van Kleef, M.A.; Duine, J.A. (1986). "Quinohaemoprotein alcohol dehydrogenase apoenzyme from Pseudomonas testosteroni". Biochem. J. 234 (3): 611–615. PMC 1146615. PMID 3521592.
  2. ↑ de Jong, G.A.; Caldeira, J.; Sun, J.; Jongejan, J.A.; de Vries, S.; Loehr, T.M.; Moura, I.; Moura, J.J.; Duine, J.A. (1995). "Characterization of the interaction between PQQ and heme c in the quinohemoprotein ethanol dehydrogenase from Comamonas testosteroni". Biochemistry. 34 (29): 9451–9458. doi:10.1021/bi00029a021. PMID 7626615.
  3. ↑ Toyama, H.; Fujii, A.; Matsushita, K.; Shinagawa, E.; Ameyama, M.; Adachi, O. (1995). "Three distinct quinoprotein alcohol dehydrogenases are expressed when Pseudomonas putida is grown on different alcohols". J. Bacteriol. 177 (9): 2442–2450. PMC 176903. PMID 7730276.
  4. ↑ Matsushita, K.; Yamashita, T.; Aoki, N.; Toyama, H.; Adachi, O. (1999). "Electron transfer from quinohemoprotein alcohol dehydrogenase to blue copper protein azurin in the alcohol oxidase respiratory chain of Pseudomonas putida HK5". Biochemistry. 38 (19): 6111–6118. doi:10.1021/bi990121f. PMID 10320337.
  5. ↑ Chen, Z.W.; Matsushita, K.; Yamashita, T.; Fujii, T.A.; Toyama, H.; Adachi, O.; Bellamy, H.D.; Mathews, F.S. (2002). "Structure at 1.9 Å resolution of a quinohemoprotein alcohol dehydrogenase from Pseudomonas putida HK5". Structure. 10 (6): 837–849. doi:10.1016/s0969-2126(02)00774-8. PMID 12057198.
  6. ↑ Oubrie, A.; Rozeboom, H.J.; Kalk, K.H.; Huizinga, E.G.; Dijkstra, B.W. (2002). "Crystal structure of quinohemoprotein alcohol dehydrogenase from Comamonas testosteroni: structural basis for substrate oxidation and electron transfer". J. Biol. Chem. 277 (5): 3727–3732. doi:10.1074/jbc.M109403200. PMID 11714714.
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