AS3MT

AS3MT
Identifiers
AliasesAS3MT, CYT19, arsenite methyltransferase
External IDsMGI: 1929882 HomoloGene: 10754 GeneCards: AS3MT
Gene location (Human)
Chr.Chromosome 10 (human)[1]
Band10q24.32Start102,869,516 bp[1]
End102,901,899 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

57412

57344

Ensembl

ENSG00000214435

ENSMUSG00000003559

UniProt

Q9HBK9

Q91WU5

RefSeq (mRNA)

NM_020682

NM_020577

RefSeq (protein)

NP_065733

NP_065602

Location (UCSC)Chr 10: 102.87 – 102.9 MbChr 19: 46.71 – 46.74 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Arsenite methyltransferase is an enzyme that in humans is encoded by the AS3MT gene.[5][6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000214435 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000003559 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Lin S, Shi Q, Nix FB, Styblo M, Beck MA, Herbin-Davis KM, Hall LL, Simeonsson JB, Thomas DJ (2002). "A novel S-adenosyl-L-methionine:arsenic(III) methyltransferase from rat liver cytosol". J. Biol. Chem. 277 (13): 10795–803. doi:10.1074/jbc.M110246200. PMID 11790780.
  6. ↑ "Entrez Gene: AS3MT arsenic (+3 oxidation state) methyltransferase".

Further reading

  • Dheeman DS, Packianathan C, Pillai JK, Rosen BP (2014). "Pathway of human AS3MT arsenic methylation". Chemical Research in Toxicology. 27 (11): 1979–89. doi:10.1021/tx500313k. PMC 4237493. PMID 25325836.
  • Hernández A, Xamena N, Sekaran C, Tokunaga H, Sampayo-Reyes A, Quinteros D, Creus A, Marcos R (2008). "High arsenic metabolic efficiency in AS3MT287Thr allele carriers". Pharmacogenet. Genomics. 18 (4): 349–55. doi:10.1097/FPC.0b013e3282f7f46b. PMID 18334919.
  • Fujihara J, Kunito T, Agusa T, Yasuda T, Iida R, Fujii Y, Takeshita H (2007). "Population differences in the human arsenic (+3 oxidation state) methyltransferase (AS3MT) gene polymorphism detected by using genotyping method". Toxicol. Appl. Pharmacol. 225 (3): 251–4. doi:10.1016/j.taap.2007.08.010. PMID 17889916.
  • Hernández A, Xamena N, Surrallés J, Sekaran C, Tokunaga H, Quinteros D, Creus A, Marcos R (2008). "Role of the Met(287)Thr polymorphism in the AS3MT gene on the metabolic arsenic profile". Mutat. Res. 637 (1–2): 80–92. doi:10.1016/j.mrfmmm.2007.07.004. PMID 17850829.
  • Lindberg AL, Kumar R, Goessler W, Thirumaran R, Gurzau E, Koppova K, Rudnai P, Leonardi G, Fletcher T, Vahter M (2007). "Metabolism of low-dose inorganic arsenic in a central European population: influence of sex and genetic polymorphisms". Environ. Health Perspect. 115 (7): 1081–6. doi:10.1289/ehp.10026. PMC 1913583. PMID 17637926.
  • Schläwicke Engström K, Broberg K, Concha G, Nermell B, Warholm M, Vahter M (2007). "Genetic polymorphisms influencing arsenic metabolism: evidence from Argentina". Environ. Health Perspect. 115 (4): 599–605. doi:10.1289/ehp.9734. PMC 1852682. PMID 17450230.
  • Meza M, Gandolfi AJ, Klimecki WT (2007). "Developmental and genetic modulation of arsenic biotransformation: a gene by environment interaction?". Toxicol. Appl. Pharmacol. 222 (3): 381–7. doi:10.1016/j.taap.2006.12.018. PMC 2040165. PMID 17306849.
  • Wood TC, Salavagionne OE, Mukherjee B, Wang L, Klumpp AF, Thomae BA, Eckloff BW, Schaid DJ, Wieben ED, Weinshilboum RM (2006). "Human arsenic methyltransferase (AS3MT) pharmacogenetics: gene resequencing and functional genomics studies". J. Biol. Chem. 281 (11): 7364–73. doi:10.1074/jbc.M512227200. PMID 16407288.
  • Meza MM, Yu L, Rodriguez YY, Guild M, Thompson D, Gandolfi AJ, Klimecki WT (2005). "Developmentally restricted genetic determinants of human arsenic metabolism: association between urinary methylated arsenic and CYT19 polymorphisms in children". Environ. Health Perspect. 113 (6): 775–81. doi:10.1289/ehp.7780. PMC 1257606. PMID 15929903.
  • Li J, Waters SB, Drobna Z, Devesa V, Styblo M, Thomas DJ (2005). "Arsenic (+3 oxidation state) methyltransferase and the inorganic arsenic methylation phenotype". Toxicol. Appl. Pharmacol. 204 (2): 164–9. doi:10.1016/j.taap.2004.12.002. PMID 15808521.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
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