8-hydroxyfuranocoumarin 8-O-methyltransferase

8-hydroxyfuranocoumarin 8-O-methyltransferase
Identifiers
EC number 2.1.1.70
CAS number 67339-13-3
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

8-hydroxyfuranocoumarin 8-O-methyltransferase (EC 2.1.1.70, furanocoumarin 8-methyltransferase, furanocoumarin 8-O-methyl-transferase, xanthotoxol 8-O-methyltransferase, XMT, SAM:xanthotoxol O-methyltransferase, S-adenosyl-L-methionine:8-hydroxyfuranocoumarin 8-O-methyltransferase, xanthotoxol methyltransferase, xanthotoxol O-methyltransferase, S-adenosyl-L-methionine:xanthotoxol O-methyltransferase, S-adenosyl-L-methionine-xanthotoxol O-methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:8-hydroxyfurocoumarin 8-O-methyltransferase.[1][2][3][4] This enzyme catalyses the following chemical reaction

(1) S-adenosyl-L-methionine + an 8-hydroxyfurocoumarin S-adenosyl-L-homocysteine + an 8-methoxyfurocoumarin (general reaction)
(2) S-adenosyl-L-methionine + xanthotoxol S-adenosyl-L-homocysteine + xanthotoxin

8-hydroxyfuranocoumarin 8-O-methyltransferase converts xanthotoxol into xanthotoxin.

References

  1. ↑ Thompson HJ, Sharma SK, Brown SA (June 1978). "O-methyltransferases of furanocoumarin biosynthesis". Archives of Biochemistry and Biophysics. 188 (2): 272–81. doi:10.1016/s0003-9861(78)80009-5. PMID 28084.
  2. ↑ Hauffe, K.D.; Hahlbrock, K.; Scheel, D. (1986). "Elicitor-stimulated furanocoumarin biosynthesis in cultured parsley cells - S-adenosyl-L-methionine-bergaptol and S-adenosyl-L-methionine-xanthotoxol O-methyltransferases". Z. Naturforsch. C. 41: 228–239.
  3. ↑ Sharma SK, Garrett JM, Brown SA (1979). "Separation of the S-adenosylmethionine: 5- and 8-hydroxyfuranocoumarin O-methyltransferases of Ruta graveolens L. by general ligand affinity chromatography". Zeitschrift Fur Naturforschung. Section C, Biosciences. 34C (5–6): 387–91. PMID 156999.
  4. ↑ Hehmann M, Lukacin R, Ekiert H, Matern U (March 2004). "Furanocoumarin biosynthesis in Ammi majus L. Cloning of bergaptol O-methyltransferase". European Journal of Biochemistry. 271 (5): 932–40. doi:10.1111/j.1432-1033.2004.03995.x. PMID 15009205.
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