23S rRNA (uridine2552-2'-O)-methyltransferase

23S rRNA (uridine2552-2'-O)-methyltransferase
Identifiers
EC number 2.1.1.166
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

23S rRNA (uridine2552-2'-O)-methyltransferase (EC 2.1.1.166, Um(2552) 23S ribosomal RNA methyltransferase, heat shock protein RrmJ, RrmJ, FTSJ, Um2552 methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (uridine2552-2'-O-)-methyltransferase.[1][2][3][4] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + uridine2552 in 23S rRNA S-adenosyl-L-homocysteine + 2'-O-methyluridine2552 in 23S rRNA

The enzyme catalyses the 2'-O-methylation of the universally conserved U2552 in the A loop of 23S rRNA.

References

  1. ↑ Caldas T, Binet E, Bouloc P, Costa A, Desgres J, Richarme G (June 2000). "The FtsJ/RrmJ heat shock protein of Escherichia coli is a 23 S ribosomal RNA methyltransferase". The Journal of Biological Chemistry. 275 (22): 16414–9. doi:10.1074/jbc.M001854200. PMID 10748051.
  2. ↑ Hager J, Staker BL, Bugl H, Jakob U (November 2002). "Active site in RrmJ, a heat shock-induced methyltransferase". The Journal of Biological Chemistry. 277 (44): 41978–86. doi:10.1074/jbc.M205423200. PMID 12181314.
  3. ↑ Hager J, Staker BL, Jakob U (October 2004). "Substrate binding analysis of the 23S rRNA methyltransferase RrmJ". Journal of Bacteriology. 186 (19): 6634–42. doi:10.1128/JB.186.19.6634-6642.2004. PMC 516604. PMID 15375145.
  4. ↑ Bügl H, Fauman EB, Staker BL, Zheng F, Kushner SR, Saper MA, Bardwell JC, Jakob U (August 2000). "RNA methylation under heat shock control". Molecular Cell. 6 (2): 349–60. doi:10.1016/S1097-2765(00)00035-6. PMID 10983982.
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