2-Deoxy-scyllo-inosamine dehydrogenase (SAM-dependent)

2-deoxy-scyllo-inosamine dehydrogenase (SAM-dependent)
Identifiers
EC number 1.1.99.38
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

2-deoxy-scyllo-inosamine dehydrogenase (SAM-dependent) (EC 1.1.99.38, btrN (gene)) is an enzyme with systematic name 2-deoxy-scyllo-inosamine:S-adenosyl-L-methionine 1-oxidoreductase.[1][2] This enzyme catalyses the following chemical reaction

2-deoxy-scyllo-inosamine + S-adenosyl-L-methionine 3-amino-2,3-dideoxy-scyllo-inosose + 5'-deoxyadenosine + L-methionine

This enzyme participates in the biosynthetic pathway of the aminoglycoside antibiotics of the butirosin family.

References

  1. ↑ Yokoyama, K.; Numakura, M.; Kudo, F.; Ohmori, D.; Eguchi, T. (2007). "Characterization and mechanistic study of a radical SAM dehydrogenase in the biosynthesis of butirosin". J. Am. Chem. Soc. 129 (49): 15147–15155. doi:10.1021/ja072481t. PMID 18001019.
  2. ↑ Yokoyama, K.; Ohmori, D.; Kudo, F.; Eguchi, T. (2008). "Mechanistic study on the reaction of a radical SAM dehydrogenase BtrN by electron paramagnetic resonance spectroscopy". Biochemistry. 47 (34): 8950–8960. doi:10.1021/bi800509x. PMID 18672902.
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