11-cis-retinol dehydrogenase

11-cis-retinol dehydrogenase
Identifiers
EC number 1.1.1.315
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

11-cis-retinol dehydrogenase (EC 1.1.1.315, RDH5 (gene)) is an enzyme with systematic name 11-cis-retinol:NAD+ oxidoreductase.[1][2][3][4] This enzyme catalyses the following chemical reaction

11-cis-retinol---[retinal-binding-protein] + NAD+ 11-cis-retinal---[retinol-binding-protein] + NADH + H+

This enzyme from retinal pigment epithelium, catalyses the reduction of 11-cis-retinol to 11-cis-retinal.

References

  1. ↑ Simon, A.; Hellman, U.; Wernstedt, C.; Eriksson, U. (1995). "The retinal pigment epithelial-specific 11-cis retinol dehydrogenase belongs to the family of short chain alcohol dehydrogenases". J. Biol. Chem. 270: 1107–1112. doi:10.1074/jbc.270.3.1107. PMID 7836368.
  2. ↑ Wang, J.; Chai, X.; Eriksson, U.; Napoli, J.L. (1999). "Activity of human 11-cis-retinol dehydrogenase (Rdh5) with steroids and retinoids and expression of its mRNA in extra-ocular human tissue". Biochem. J. 338: 23–27. doi:10.1042/0264-6021:3380023. PMC 1220019. PMID 9931293.
  3. ↑ Liden, M.; Romert, A.; Tryggvason, K.; Persson, B.; Eriksson, U. (2001). "Biochemical defects in 11-cis-retinol dehydrogenase mutants associated with fundus albipunctatus". J. Biol. Chem. 276 (52): 49251–49257. doi:10.1074/jbc.M107337200. PMID 11675386.
  4. ↑ Wu, Z.; Yang, Y.; Shaw, N.; Bhattacharya, S.; Yan, L.; West, K.; Roth, K.; Noy, N.; Qin, J.; Crabb, J.W. (2003). "Mapping the ligand binding pocket in the cellular retinaldehyde binding protein". J. Biol. Chem. 278: 12390–12396. doi:10.1074/jbc.M212775200. PMID 12536149.
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