Undecaprenyl-phosphate mannosyltransferase
In enzymology, an undecaprenyl-phosphate mannosyltransferase (EC 2.4.1.54) is an enzyme that catalyzes the chemical reaction
- GDP-mannose + undecaprenyl phosphate GDP + D-mannosyl-1-phosphoundecaprenol
| undecaprenyl-phosphate mannosyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.4.1.54 | ||||||||
| CAS number | 37277-62-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are GDP-mannose and undecaprenyl phosphate, whereas its two products are GDP and D-mannosyl-1-phosphoundecaprenol.
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is GDP-mannose:undecaprenyl-phosphate D-mannosyltransferase. Other names in common use include guanosine diphosphomannose-undecaprenyl phosphate, mannosyltransferase, GDP mannose-undecaprenyl phosphate mannosyltransferase, and GDP-D-mannose:lipid phosphate transmannosylase. It employs one cofactor, phosphatidylglycerol. Sources of this enzyme includes Micrococcus luteus, Phaseolus aureus, Mycobacterium smegmatis and cotton fibers.
References
- Lahav M, Chiu TH, Lennarz WJ (1969). "Studies on the biosynthesis of mannan in Micrococcus lysodeikticus II. The enzymatic synthesis of mannosyl-l-phosphoryl-undecaprenol". J. Biol. Chem. 244 (21): 5890–8. PMID 5350943.