Type XVIII collagen

collagen, type XVIII, alpha 1
Identifiers
Symbol	COL18A1
NCBI gene	80781
HGNC	2195
OMIM	120328
RefSeq	NM_130445
UniProt	P39060
Other data
Locus	Chr. 21 q22.3

Type XVIII collagen is a type of collagen which can be cleaved to form endostatin. The endostatin is from the c terminus end of the collagen XVIII, and is known to have an inhibitory effect on the growth of blood vessels. This is seen with tumors, where endostatin inhibits the growth of the blood vessels of the tumor as well as the overall growth of the tumor. [1]

The collagen XVIII is located within the basement membrane, and plays a major role in the integrity of the structure of the basement membrane for both endothelial and epithelial cells.[2] The collagen XVIII has three different isoforms. While each of the isoforms has the same C-terminus end, they have a varying structure on the N-terminus end, which results in the formation of short, medium or long form Collagen XVIII. [3]

References

Heljasvaara R, Aikio M, Ruotsalainen H, Pihlajaniemi T (January 2017). "Collagen XVIII in tissue homeostasis and dysregulation - Lessons learned from model organisms and human patients". Matrix Biology. 57-58: 55–75. doi:10.1016/j.matbio.2016.10.002. PMID 27746220.
Rygh CB, Løkka G, Heljasvaara R, Taxt T, Pavlin T, Sormunen R, et al. (January 2014). "Image-based assessment of microvascular function and structure in collagen XV- and XVIII-deficient mice". The Journal of Physiology. 592 (2): 325–36. doi:10.1113/jphysiol.2013.263574. PMC 3922497. PMID 24218547.
Kinnunen AI, Sormunen R, Elamaa H, Seppinen L, Miller RT, Ninomiya Y, et al. (March 2011). "Lack of collagen XVIII long isoforms affects kidney podocytes, whereas the short form is needed in the proximal tubular basement membrane". The Journal of Biological Chemistry. 286 (10): 7755–64. doi:10.1074/jbc.m110.166132. PMC 3048663. PMID 21193414.

External links

Collagen+Type+XVIII at the US National Library of Medicine Medical Subject Headings (MeSH)

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[1] Heljasvaara R, Aikio M, Ruotsalainen H, Pihlajaniemi T (January 2017). "Collagen XVIII in tissue homeostasis and dysregulation - Lessons learned from model organisms and human patients". Matrix Biology. 57-58: 55–75. doi:10.1016/j.matbio.2016.10.002. PMID 27746220.

[2] Rygh CB, Løkka G, Heljasvaara R, Taxt T, Pavlin T, Sormunen R, et al. (January 2014). "Image-based assessment of microvascular function and structure in collagen XV- and XVIII-deficient mice". The Journal of Physiology. 592 (2): 325–36. doi:10.1113/jphysiol.2013.263574. PMC 3922497. PMID 24218547.

[3] Kinnunen AI, Sormunen R, Elamaa H, Seppinen L, Miller RT, Ninomiya Y, et al. (March 2011). "Lack of collagen XVIII long isoforms affects kidney podocytes, whereas the short form is needed in the proximal tubular basement membrane". The Journal of Biological Chemistry. 286 (10): 7755–64. doi:10.1074/jbc.m110.166132. PMC 3048663. PMID 21193414.