SMC1B

Structural maintenance of chromosomes protein 1B (SMC-1B) is a protein that in humans is encoded by the SMC1B gene.[5][6][7] SMC-1B belongs to a family of proteins required for chromatid cohesion and DNA recombination during meiosis and mitosis.[7] SMC1ß protein appears to participate with other cohesins REC8, STAG3 and SMC3 in sister-chromatid cohesion throughout the whole meiotic process in human oocytes.[8]

SMC1B
Identifiers
AliasesSMC1B, SMC1BETA, SMC1L2, structural maintenance of chromosomes 1B
External IDsOMIM: 608685 MGI: 2154049 HomoloGene: 13786 GeneCards: SMC1B
Gene location (Human)
Chr.Chromosome 22 (human)[1]
Band22q13.31Start45,344,063 bp[1]
End45,413,619 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

27127

140557

Ensembl

ENSG00000077935

ENSMUSG00000022432

UniProt

Q8NDV3

Q920F6

RefSeq (mRNA)

NM_001291501
NM_148674

NM_080470

RefSeq (protein)

NP_001278430
NP_683515

NP_536718

Location (UCSC)Chr 22: 45.34 – 45.41 MbChr 15: 85.06 – 85.13 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

References

  1. GRCh38: Ensembl release 89: ENSG00000077935 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000022432 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: structural maintenance of chromosomes 1B".
  6. Dunham I; Shimizu N; Roe BA; Chissoe S; Hunt AR; Collins JE; Bruskiewich R; Beare DM; Clamp M; Smink LJ; Ainscough R; Almeida JP; Babbage A; Bagguley C; Bailey J; Barlow K; Bates KN; Beasley O; Bird CP; Blakey S; Bridgeman AM; Buck D; Burgess J; Burrill WD; O'Brien KP (December 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
  7. Revenkova E; Eijpe M; Heyting C; Gross B; Jessberger R (October 2001). "Novel meiosis-specific isoform of mammalian SMC1". Mol. Cell. Biol. 21 (20): 6984–98. doi:10.1128/MCB.21.20.6984-6998.2001. PMC 99874. PMID 11564881.
  8. Garcia-Cruz R, Brieño MA, Roig I, Grossmann M, Velilla E, Pujol A, Cabero L, Pessarrodona A, Barbero JL, Garcia Caldés M (2010). "Dynamics of cohesin proteins REC8, STAG3, SMC1 beta and SMC3 are consistent with a role in sister chromatid cohesion during meiosis in human oocytes". Hum. Reprod. 25 (9): 2316–27. doi:10.1093/humrep/deq180. PMID 20634189.

Further reading

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