PRPF40A

Pre-mRNA-processing factor 40 homolog A is a protein that in humans is encoded by the PRPF40A gene.[5][6][7]

PRPF40A
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPRPF40A, FBP-11, FBP11, FLAF1, FNBP3, HIP-10, HIP10, HYPA, NY-REN-6, Prp40, pre-mRNA processing factor 40 homolog A
External IDsOMIM: 612941 MGI: 1860512 HomoloGene: 6377 GeneCards: PRPF40A
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2q23.3Start152,651,593 bp[1]
End152,717,997 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

55660

56194

Ensembl

ENSG00000196504

ENSMUSG00000061136

UniProt

O75400

Q9R1C7

RefSeq (mRNA)

NM_018785

RefSeq (protein)
Location (UCSC)Chr 2: 152.65 – 152.72 MbChr 2: 53.13 – 53.19 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

PRPF40A has been shown to interact with Huntingtin.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000196504 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000061136 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Bedford MT, Reed R, Leder P (September 1998). "WW domain-mediated interactions reveal a spliceosome-associated protein that binds a third class of proline-rich motif: the proline glycine and methionine-rich motif". Proc Natl Acad Sci U S A. 95 (18): 10602–7. Bibcode:1998PNAS...9510602B. doi:10.1073/pnas.95.18.10602. PMC 27941. PMID 9724750.
  6. Wiesner S, Stier G, Sattler M, Macias MJ (December 2002). "Solution structure and ligand recognition of the WW domain pair of the yeast splicing factor Prp40". J Mol Biol. 324 (4): 807–22. doi:10.1016/S0022-2836(02)01145-2. PMID 12460579.
  7. "Entrez Gene: PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)".
  8. Faber, P W; Barnes G T; Srinidhi J; Chen J; Gusella J F; MacDonald M E (September 1998). "Huntingtin interacts with a family of WW domain proteins". Hum. Mol. Genet. 7 (9): 1463–74. doi:10.1093/hmg/7.9.1463. ISSN 0964-6906. PMID 9700202.

Further reading

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