DCP1B

DCP1B
Identifiers
Aliases	DCP1B, DCP1, hDcp1b, decapping mRNA 1B
External IDs	OMIM: 609843 MGI: 2442404 HomoloGene: 51881 GeneCards: DCP1B
Gene location (Human)
Chr.	Chromosome 12 (human)[1]
End	2,004,535 bp[1]
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)[2]
End	119,221,616 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• enzyme regulator activity; • enzyme activator activity; • GO:0001948 protein binding; • mRNA binding; • hydrolase activity;
Cellular component	• P-body; • membrane; • intracellular membrane-bounded organelle; • cell nucleus; • cytoplasm; • cytosol;
Biological process	• nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; • positive regulation of catalytic activity; • deadenylation-independent decapping of nuclear-transcribed mRNA; • deadenylation-dependent decapping of nuclear-transcribed mRNA; • exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay;
	Sources:Amigo / QuickGO
Orthologs
	196513
	319618
	ENSG00000151065; ENSG00000284850
	ENSMUSG00000041477
	Q8IZD4
	Q3U564
	NM_152640; NM_001319292
	NM_001033379
	NP_001306221; NP_689853
	NP_001028551
	Wikidata
View/Edit Human	View/Edit Mouse

mRNA-decapping enzyme 1B is a protein that in humans is encoded by the DCP1B gene.[5][6][7]

DCP1B is a core component of the mRNA decapping complex, a key factor in the regulation of mRNA decay (Lykke-Andersen, 2002).[supplied by OMIM][7]

References

Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

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