DCP2

DCP2
Identifiers
Aliases	DCP2, NUDT20, decapping mRNA 2
External IDs	OMIM: 609844 MGI: 1917890 HomoloGene: 13968 GeneCards: DCP2
Gene location (Human)
Chr.	Chromosome 5 (human)[1]
End	113,022,195 bp[1]
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)[2]
End	44,424,969 bp[2]
Gene ontology
Molecular function	• m7G(5')pppN diphosphatase activity; • manganese ion binding; • metal ion binding; • GO:0001948 protein binding; • exoribonuclease activity, producing 5'-phosphomonoesters; • RNA binding; • hydrolase activity; • 5'-3' exoribonuclease activity; • telomerase RNA binding;
Cellular component	• cytoplasm; • RISC complex; • cytosol; • P-body; • nucleoplasm; • cell junction; • cell nucleus; • cytoplasmic ribonucleoprotein granule;
Biological process	• mRNA catabolic process; • regulation of mRNA stability; • deadenylation-dependent decapping of nuclear-transcribed mRNA; • exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay; • histone mRNA catabolic process; • RNA phosphodiester bond hydrolysis, exonucleolytic; • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; • negative regulation of telomere maintenance via telomerase; • regulation of telomerase RNA localization to Cajal body;
	Sources:Amigo / QuickGO
Orthologs
	167227
	70640
	ENSG00000172795
	ENSMUSG00000024472
	Q8IU60
	Q9CYC6
	NM_001242377; NM_152624
	NM_027490
	NP_001229306; NP_689837
	NP_081766
	Wikidata
View/Edit Human	View/Edit Mouse

mRNA-decapping enzyme 2 is a protein that in humans is encoded by the DCP2 gene.[5][6][7]

DCP2 is a key component of an mRNA-decapping complex required for removal of the 5-prime cap from mRNA prior to its degradation from the 5-prime end (Fenger-Gron et al., 2005).[supplied by OMIM][7]

Interactions

DCP2 has been shown to interact with DCP1A[8] and UPF1.[6][9]

References

GRCh38: Ensembl release 89: ENSG00000172795 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000024472 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Wang Z, Jiao X, Carr-Schmid A, Kiledjian M (Oct 2002). "The hDcp2 protein is a mammalian mRNA decapping enzyme pro-caratine". Proc Natl Acad Sci U S A. 99 (20): 12663–8. Bibcode:2002PNAS...9912663W. doi:10.1073/pnas.192445599. PMC 130517. PMID 12218187.
Lykke-Andersen J (Nov 2002). "Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay". Mol Cell Biol. 22 (23): 8114–21. doi:10.1128/MCB.22.23.8114-8121.2002. PMC 134073. PMID 12417715.
"Entrez Gene: DCP2 DCP2 decapping enzyme homolog (S. cerevisiae)".
Lykke-Andersen, Jens (Dec 2002). "Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay". Mol. Cell. Biol. 22 (23): 8114–21. doi:10.1128/MCB.22.23.8114-8121.2002. ISSN 0270-7306. PMC 134073. PMID 12417715.
Lejeune, Fabrice; Li Xiaojie; Maquat Lynne E (Sep 2003). "Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities". Mol. Cell. 12 (3): 675–87. doi:10.1016/S1097-2765(03)00349-6. ISSN 1097-2765. PMID 14527413.

Ueno K, Kumagai T, Kijima T, et al. (1998). "Cloning and tissue expression of cDNAs from chromosome 5q21-22 which is frequently deleted in advanced lung cancer". Hum. Genet. 102 (1): 63–8. doi:10.1007/s004390050655. PMID 9490301.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
van Dijk E, Cougot N, Meyer S, et al. (2004). "Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures". EMBO J. 21 (24): 6915–24. doi:10.1093/emboj/cdf678. PMC 139098. PMID 12486012.
Ingelfinger D, Arndt-Jovin DJ, Lührmann R, Achsel T (2003). "The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci". RNA. 8 (12): 1489–501. doi:10.1017/S1355838202021726 (inactive 2020-01-22). PMC 1370355. PMID 12515382.
Grzymski EC (2003). "Visualizing an mRNA destruction line". Nat. Struct. Biol. 10 (6): 416. doi:10.1038/nsb0603-416. PMID 12768200.
Piccirillo C, Khanna R, Kiledjian M (2003). "Functional characterization of the mammalian mRNA decapping enzyme hDcp2". RNA. 9 (9): 1138–47. doi:10.1261/rna.5690503. PMC 1370477. PMID 12923261.
Lejeune F, Li X, Maquat LE (2003). "Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities". Mol. Cell. 12 (3): 675–87. doi:10.1016/S1097-2765(03)00349-6. PMID 14527413.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Cougot N, Babajko S, Séraphin B (2004). "Cytoplasmic foci are sites of mRNA decay in human cells". J. Cell Biol. 165 (1): 31–40. doi:10.1083/jcb.200309008. PMC 2172085. PMID 15067023.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
Liu SW, Jiao X, Liu H, et al. (2004). "Functional analysis of mRNA scavenger decapping enzymes". RNA. 10 (9): 1412–22. doi:10.1261/rna.7660804. PMC 1370627. PMID 15273322.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Liu J, Valencia-Sanchez MA, Hannon GJ, Parker R (2005). "MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies". Nat. Cell Biol. 7 (7): 719–23. doi:10.1038/ncb1274. PMC 1855297. PMID 15937477.
Fenger-Grøn M, Fillman C, Norrild B, Lykke-Andersen J (2006). "Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping". Mol. Cell. 20 (6): 905–15. doi:10.1016/j.molcel.2005.10.031. PMID 16364915.
Wichroski MJ, Robb GB, Rana TM (2006). "Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies". PLoS Pathog. 2 (5): e41. doi:10.1371/journal.ppat.0020041. PMC 1458959. PMID 16699599.
Chu CY, Rana TM (2006). "Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54". PLoS Biol. 4 (7): e210. doi:10.1371/journal.pbio.0040210. PMC 1475773. PMID 16756390.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000172795 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024472 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12218187-5] Wang Z, Jiao X, Carr-Schmid A, Kiledjian M (Oct 2002). "The hDcp2 protein is a mammalian mRNA decapping enzyme pro-caratine". Proc Natl Acad Sci U S A. 99 (20): 12663–8. Bibcode:2002PNAS...9912663W. doi:10.1073/pnas.192445599. PMC 130517. PMID 12218187.

[pmid12417715-6] Lykke-Andersen J (Nov 2002). "Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay". Mol Cell Biol. 22 (23): 8114–21. doi:10.1128/MCB.22.23.8114-8121.2002. PMC 134073. PMID 12417715.

[entrez-7] "Entrez Gene: DCP2 DCP2 decapping enzyme homolog (S. cerevisiae)".

[autogenerated1-8] Lykke-Andersen, Jens (Dec 2002). "Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay". Mol. Cell. Biol. 22 (23): 8114–21. doi:10.1128/MCB.22.23.8114-8121.2002. ISSN 0270-7306. PMC 134073. PMID 12417715.

[pmid14527413-9] Lejeune, Fabrice; Li Xiaojie; Maquat Lynne E (Sep 2003). "Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities". Mol. Cell. 12 (3): 675–87. doi:10.1016/S1097-2765(03)00349-6. ISSN 1097-2765. PMID 14527413.

DCP2

Interactions

References

Further reading