OR10J5

OR10J5
Identifiers
Aliases	OR10J5, OR1-28, olfactory receptor family 10 subfamily J member 5
External IDs	MGI: 106648 HomoloGene: 7460 GeneCards: OR10J5
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	159,536,007 bp[1]
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)[2]
End	172,958,357 bp[2]
Gene ontology
Molecular function	• G-protein coupled receptor activity; • olfactory receptor activity; • signal transducer activity; • neurotransmitter receptor activity; • G-protein coupled serotonin receptor activity;
Cellular component	• integral component of membrane; • cell membrane; • membrane; • integral component of plasma membrane; • dendrite;
Biological process	• sensory perception of smell; • detection of chemical stimulus involved in sensory perception of smell; • signal transduction; • response to stimulus; • G-protein coupled serotonin receptor signaling pathway; • G-protein coupled receptor signaling pathway; • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; • chemical synaptic transmission;
	Sources:Amigo / QuickGO
Orthologs
	127385
	18313
	ENSG00000184155
	ENSMUSG00000037924
	Q8NHC4
	Q62007
	NM_001004469
	NM_008763
	NP_001004469
	NP_032789
	Wikidata
View/Edit Human	View/Edit Mouse

Olfactory receptor 10J5 is a protein that in humans is encoded by the OR10J5 gene.[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]

Ligands

OR10J5 is a relatively narrowly-tuned receptor, meaning it responds only to a relatively small set of related odorants.[6]

Ligands include Lyral,[6] an aldehyde with a soft floral scent.

References

GRCh38: Ensembl release 89: ENSG00000184155 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000037924 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: OR10J5 olfactory receptor, family 10, subfamily J, member 5".
Saito H, Chi Q, Zhuang H, Matsunami H, Mainland JD (March 2009). "Odor coding by a Mammalian receptor repertoire". Science Signaling. 2 (60): ra9. doi:10.1126/scisignal.2000016. PMC 2774247. PMID 19261596.

External links

OR10J5+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000184155 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037924 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: OR10J5 olfactory receptor, family 10, subfamily J, member 5".

[pmid19261596-6] Saito H, Chi Q, Zhuang H, Matsunami H, Mainland JD (March 2009). "Odor coding by a Mammalian receptor repertoire". Science Signaling. 2 (60): ra9. doi:10.1126/scisignal.2000016. PMC 2774247. PMID 19261596.

OR10J5

Ligands

References

Further reading

External links