NEU4

Sialidase-4 is an enzyme that in humans is encoded by the NEU4 gene.[5]

NEU4
Identifiers
AliasesNEU4, neuraminidase 4
External IDsOMIM: 608527 MGI: 2661364 HomoloGene: 15433 GeneCards: NEU4
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2q37.3Start241,808,825 bp[1]
End241,817,413 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

129807

241159

Ensembl

ENSG00000204099
ENSG00000277926

ENSMUSG00000034000

UniProt

Q8WWR8

Q8BZL1

RefSeq (mRNA)

NM_080741
NM_001167599
NM_001167600
NM_001167601
NM_001167602

NM_173772
NM_001310769

RefSeq (protein)

NP_001297698
NP_776133

Location (UCSC)Chr 2: 241.81 – 241.82 MbChr 1: 94.02 – 94.03 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids.[5]

Interactions

NEU4 has been shown to interact with PLSCR1.[6]

References
  1. ENSG00000277926 GRCh38: Ensembl release 89: ENSG00000204099, ENSG00000277926 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000034000 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: NEU4 sialidase 4".
  6. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.

Further reading
  • Comelli EM, Amado M, Lustig SR, Paulson JC (2004). "Identification and expression of Neu4, a novel murine sialidase". Gene. 321: 155–61. doi:10.1016/j.gene.2003.08.005. PMID 14637003.
  • Monti E, Bassi MT, Bresciani R, Civini S, Croci GL, Papini N, Riboni M, Zanchetti G, Ballabio A, Preti A, Tettamanti G, Venerando B, Borsani G (2004). "Molecular cloning and characterization of NEU4, the fourth member of the human sialidase gene family". Genomics. 83 (3): 445–53. doi:10.1016/j.ygeno.2003.08.019. PMID 14962670.
  • Seyrantepe V, Landry K, Trudel S, Hassan JA, Morales CR, Pshezhetsky AV (2004). "Neu4, a novel human lysosomal lumen sialidase, confers normal phenotype to sialidosis and galactosialidosis cells". J. Biol. Chem. 279 (35): 37021–9. doi:10.1074/jbc.M404531200. PMID 15213228.
  • Wan D, Gong Y, Qin W, Zhang P, Li J, Wei L, Zhou X, Li H, Qiu X, Zhong F, He L, Yu J, Yao G, Jiang H, Qian L, Yu Y, Shu H, Chen X, Xu H, Guo M, Pan Z, Chen Y, Ge C, Yang S, Gu J (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
  • Stamatos NM, Liang F, Nan X, Landry K, Cross AS, Wang LX, Pshezhetsky AV (2005). "Differential expression of endogenous sialidases of human monocytes during cellular differentiation into macrophages". FEBS J. 272 (10): 2545–56. doi:10.1111/j.1742-4658.2005.04679.x. PMID 15885103.


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