NEU3

NEU3
Identifiers
Aliases	NEU3, SIAL3, neuraminidase 3 (membrane sialidase), neuraminidase 3, membrane sialidase, neuraminidase 3
External IDs	OMIM: 604617 MGI: 1355305 HomoloGene: 4847 GeneCards: NEU3
Gene location (Human)
Chr.	Chromosome 11 (human)[1]
End	75,018,893 bp[1]
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)[2]
End	99,828,417 bp[2]
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• alpha-sialidase activity; • exo-alpha-(2->6)-sialidase activity; • exo-alpha-(2->8)-sialidase activity; • hydrolase activity, acting on glycosyl bonds; • exo-alpha-(2->3)-sialidase activity; • hydrolase activity; • exo-alpha-sialidase activity;
Cellular component	• cytoplasm; • intracellular membrane-bounded organelle; • membrane; • cell membrane; • integral component of plasma membrane;
Biological process	• glycosphingolipid metabolic process; • lipid metabolism; • lipid catabolic process; • oligosaccharide catabolic process; • metabolism; • ganglioside catabolic process; • carbohydrate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	10825
	50877
	ENSG00000162139
	ENSMUSG00000035239
	Q9UQ49
	Q9JMH7
	NM_006656
	NM_016720
NP_006647; NP_001354789; NP_001354790; NP_001354791; NP_001354792;
	NP_001354793; NP_001354794; NP_001354795; NP_001354796
	NP_057929
	Wikidata
View/Edit Human	View/Edit Mouse

Sialidase-3 is an enzyme that in humans is encoded by the NEU3 gene.[5][6]

Function

This gene product belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. It is localized in the plasma membrane, and its activity is specific for gangliosides. It may play a role in modulating the ganglioside content of the lipid bilayer.[6]

Interactions

NEU3 has been shown to interact with Grb2.[7]

References

GRCh38: Ensembl release 89: ENSG00000162139 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000035239 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Wada T, Yoshikawa Y, Tokuyama S, Kuwabara M, Akita H, Miyagi T (Aug 1999). "Cloning, expression, and chromosomal mapping of a human ganglioside sialidase". Biochem Biophys Res Commun. 261 (1): 21–7. doi:10.1006/bbrc.1999.0973. PMID 10405317.
"Entrez Gene: NEU3 sialidase 3 (membrane sialidase)".
Sasaki A, Hata K, Suzuki S, Sawada M, Wada T, Yamaguchi K, Obinata M, Tateno H, Suzuki H, Miyagi T (Jul 2003). "Overexpression of plasma membrane-associated sialidase attenuates insulin signaling in transgenic mice". J. Biol. Chem. 278 (30): 27896–902. doi:10.1074/jbc.M212200200. PMID 12730204.

Hu H, Shioda T, Moriya C, Xin X, Hasan MK, Miyake K, Shimada T, Nagai Y (1996). "Infectivities of human and other primate lentiviruses are activated by desialylation of the virion surface". J. Virol. 70 (11): 7462–70. doi:10.1128/JVI.70.11.7462-7470.1996. PMC 190813. PMID 8892864.
Monti E, Bassi MT, Papini N, Riboni M, Manzoni M, Venerando B, Croci G, Preti A, Ballabio A, Tettamanti G, Borsani G (2001). "Identification and expression of NEU3, a novel human sialidase associated to the plasma membrane". Biochem. J. 349 (Pt 1): 343–51. doi:10.1042/0264-6021:3490343. PMC 1221155. PMID 10861246.
Wang Y, Yamaguchi K, Wada T, Hata K, Zhao X, Fujimoto T, Miyagi T (2002). "A close association of the ganglioside-specific sialidase Neu3 with caveolin in membrane microdomains". J. Biol. Chem. 277 (29): 26252–9. doi:10.1074/jbc.M110515200. PMID 12011038.
Kakugawa Y, Wada T, Yamaguchi K, Yamanami H, Ouchi K, Sato I, Miyagi T (2002). "Up-regulation of plasma membrane-associated ganglioside sialidase (Neu3) in human colon cancer and its involvement in apoptosis suppression". Proc. Natl. Acad. Sci. U.S.A. 99 (16): 10718–23. Bibcode:2002PNAS...9910718K. doi:10.1073/pnas.152597199. PMC 125023. PMID 12149448.
Hart ML, Saifuddin M, Uemura K, Bremer EG, Hooker B, Kawasaki T, Spear GT (2003). "High mannose glycans and sialic acid on gp120 regulate binding of mannose-binding lectin (MBL) to HIV type 1". AIDS Res. Hum. Retroviruses. 18 (17): 1311–7. doi:10.1089/088922202320886352. PMID 12487819.
Oehler C, Kopitz J, Cantz M (2003). "Substrate specificity and inhibitor studies of a membrane-bound ganglioside sialidase isolated from human brain tissue". Biol. Chem. 383 (11): 1735–42. doi:10.1515/BC.2002.194. PMID 12530538.
Sasaki A, Hata K, Suzuki S, Sawada M, Wada T, Yamaguchi K, Obinata M, Tateno H, Suzuki H, Miyagi T (2003). "Overexpression of plasma membrane-associated sialidase attenuates insulin signaling in transgenic mice". J. Biol. Chem. 278 (30): 27896–902. doi:10.1074/jbc.M212200200. PMID 12730204.
Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
Ha KT, Lee YC, Cho SH, Kim JK, Kim CH (2004). "Molecular characterization of membrane type and ganglioside-specific sialidase (Neu3) expressed in E. coli". Mol. Cells. 17 (2): 267–73. PMID 15179041.
Stamatos NM, Liang F, Nan X, Landry K, Cross AS, Wang LX, Pshezhetsky AV (2005). "Differential expression of endogenous sialidases of human monocytes during cellular differentiation into macrophages". FEBS J. 272 (10): 2545–56. doi:10.1111/j.1742-4658.2005.04679.x. PMID 15885103.
Kato K, Shiga K, Yamaguchi K, Hata K, Kobayashi T, Miyazaki K, Saijo S, Miyagi T (2006). "Plasma-membrane-associated sialidase (NEU3) differentially regulates integrin-mediated cell proliferation through laminin- and fibronectin-derived signalling". Biochem. J. 394 (Pt 3): 647–56. doi:10.1042/BJ20050737. PMC 1383714. PMID 16241905.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Ueno S, Saito S, Wada T, Yamaguchi K, Satoh M, Arai Y, Miyagi T (2006). "Plasma membrane-associated sialidase is up-regulated in renal cell carcinoma and promotes interleukin-6-induced apoptosis suppression and cell motility". J. Biol. Chem. 281 (12): 7756–64. doi:10.1074/jbc.M509668200. PMID 16428383.
Yamaguchi K, Hata K, Wada T, Moriya S, Miyagi T (2006). "Epidermal growth factor-induced mobilization of a ganglioside-specific sialidase (NEU3) to membrane ruffles". Biochem. Biophys. Res. Commun. 346 (2): 484–90. doi:10.1016/j.bbrc.2006.05.136. PMID 16765317.
Nan X, Carubelli I, Stamatos NM (2007). "Sialidase expression in activated human T lymphocytes influences production of IFN-gamma". J. Leukoc. Biol. 81 (1): 284–96. CiteSeerX 10.1.1.492.9566. doi:10.1189/jlb.1105692. PMID 17028199.
Yoshizumi S, Suzuki S, Hirai M, Hinokio Y, Yamada T, Yamada T, Tsunoda U, Aburatani H, Yamaguchi K, Miyagi T, Oka Y (2007). "Increased hepatic expression of ganglioside-specific sialidase, NEU3, improves insulin sensitivity and glucose tolerance in mice". Metab. Clin. Exp. 56 (3): 420–9. doi:10.1016/j.metabol.2006.10.027. PMID 17292733.
Wada T, Hata K, Yamaguchi K, Shiozaki K, Koseki K, Moriya S, Miyagi T (2007). "A crucial role of plasma membrane-associated sialidase in the survival of human cancer cells". Oncogene. 26 (17): 2483–90. doi:10.1038/sj.onc.1210341. PMID 17334392.
Azuma Y, Sato H, Higai K, Matsumoto K (2007). "Enhanced expression of membrane-associated sialidase Neu3 decreases GD3 and increases GM3 on the surface of Jurkat cells during etoposide-induced apoptosis". Biol. Pharm. Bull. 30 (9): 1680–4. doi:10.1248/bpb.30.1680. PMID 17827720.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000162139 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000035239 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10405317-5] Wada T, Yoshikawa Y, Tokuyama S, Kuwabara M, Akita H, Miyagi T (Aug 1999). "Cloning, expression, and chromosomal mapping of a human ganglioside sialidase". Biochem Biophys Res Commun. 261 (1): 21–7. doi:10.1006/bbrc.1999.0973. PMID 10405317.

[entrez-6] "Entrez Gene: NEU3 sialidase 3 (membrane sialidase)".

[pmid12730204-7] Sasaki A, Hata K, Suzuki S, Sawada M, Wada T, Yamaguchi K, Obinata M, Tateno H, Suzuki H, Miyagi T (Jul 2003). "Overexpression of plasma membrane-associated sialidase attenuates insulin signaling in transgenic mice". J. Biol. Chem. 278 (30): 27896–902. doi:10.1074/jbc.M212200200. PMID 12730204.

NEU3

Function

Interactions

References

Further reading