Imortal

The main female protagonist of the series. The youngest daughter of Noah and Lyka. She is the chosen one of the werewolves. Her ability as a werewolf can burn vampires using her hands when touched. She has stronger powers than her mother Lyka who bestowed on her a special protection against vampires just before she died.[7]

The main male protagonist of the series. The son of Roman, the vampire and Ceres, a mortal. He was the first known child born out of such a union. He was the only human child who lived with the vampire community in his first seven years. His father wanted to integrate him with the werewolf and mortal community, but his attempted peace talk with Lyka failed because he was double-crossed by Magnus. He was later adopted by Simon Teodoro and grew up in the Teodoro household with Lucas, Simon's natural child. He is the chosen one of the vampires as he is the strongest vampire. He was turned into a vampire after he died in a battle against werewolves. He loved Lia and together with her defeated the Magnus, Lucas and the Hybrid army.

Began as one of the minor antagonists of the series, then switched allegiance to Mateo and Lia and became one of their strongest allies, She is the adopted vampire daughter of Magnus Imperial. Her mother was bitten by Magnus while pregnant in a desperate attempt to sire the chosen vampire. Magnus raised her as the anointed “chosen one”, mistakenly believing Barang's prophecy that the savior would come from his lineage.[8] Samantha grew up believing that she is the strongest vampire who would lead her clan in the battle against the werewolves and their Chosen One. She eventually learns that she is mistaken, and the "Chosen One" is revealed to be Mateo. Samantha falls in love with Mateo and fulfills the third part of the prophecy, "the bite of pure love", by turning a dying Mateo into a vampire to save his life. She joins Roman's community of righteous vampires, betraying her own father, Magnus. She becomes one of Mateo's and Lia's strongest allies. Lucas injures her in battle through his venom, and chooses to kill herself rather than become a hybrid.

The main antagonist of the series. He is the son of Simon Teodoro and adoptive brother of Mateo. His mother is a fourth generation Ungson clan, one of the powerful clans of the Wayas. He became a hybrid after Magnus bit him. He built an army of Hybrids that threatened all vampires, humans and werewolves.

Lyka's colleague at the Waya Council and uncle of Lia. He has a daughter named Miriam. He acted as Lia's surrogate father and guardian after Lyka died. He protected Lia from the abusive Head Guardian Lucille Zaragoza.

The main female antagonist of the series. Former head guardian of the Waya who succeeded Lyka after Lyka resigned following her family's assassination by vampires. She will do everything to keep the leadership of the Waya council, going as far as destroying Lyka's legacy as the last guardian, who saved her race from extinction during the red moon. She stripped the orphaned Lia of her privileged status and relegated her to a life of servitude. She abused and tormented Lia. At the end, she realized her errors and joined Lia and Mateo's forces. She killed Magnus but died in the process.

The main male antagonist of the series. The founder and leader of the Club Sangre, an organization of evil vampires that aims to eliminate all werewolves to save their race. He was Samantha Imperial's adoptive father. He was Roman's enemy who sabotaged Roman's peace efforts with Lyka. He killed Lyka at the surprise raid of Lyka's home.

The female antagonist of the series. She was Magnus' lover, who turned him into a vampire because she was in love with him. Her lovers and husbands died except Magnus. She turned against Magnus at the end of the series and joined Mateo and Lia's alliances.

One of the minor antagonists of the series. The daughter of Lucille and a member of the Waya council. She has an antagonistic relationship with Lia since childhood and is desperately in love with Mateo. She chose to align with Lia when she realized her mother's self-serving actions. She saved Mateo from the public execution her mother ordered, and joined the Luna forces in the last battle against Magnus’ Force.

The colleague of Roman. She was the foster mother of Mateo during his childhood. She led Roman's community and helped vampires transition from human blood drinkers to animal blood drinkers.

The owner of Simon Landholdings Inc. He is the father of Lucas and adoptive father of Mateo, who rescued him from the streets. He trusted Mateo over Lucas.

The father of Mateo. He was the founder of the community of good vampires, who only drank animal blood. He attempted to reach out to Lyka to begin peace talks between vampires and werewolves as he believed they could peacefully coexist. He believed vampires didn't need human blood to survive and his community proved this possible.

The father of Jethro. He was a seer but is powerless since his powers passed to his son. He was also in Lobo as a child, played by Nash Aguas who could communicate with animals.

The son of Tikboy and was a seer. He was also the blogger who posted the upcoming prophecy. The friend of Olive and he fell in love with her. His feelings were hurt when Olive chose Gael over Jethro in the grand opening of La Liga Unida, an organization for the peaceful friendship of werewolves, vampires, and mortals.

Dara's niece and Jethro's love interest. Her first love was Jethro until she met Gael who turned her into a vampire. She ended up having a mutual relationship with Gael.

He was a vampire ally of Magnus. He fell in love and has a mutual relationship with Olive. He switched his alliance to Lia and Mateo.

A member of the Waya's werewolf army and Lia's friend. He became Clarisse's boyfriend.

A member of the Waya's werewolf army, Lia's friend and Vergara's assistant.

The vampire best friend of Samantha who was in love with her.