Chlorisondamine

Chlorisondamine
Clinical data
ATC code	None;
Identifiers
	IUPAC name Trimethyl-[2-(4,5,6,7-tetrachloro-2-methyl-isoindolin-2-ium-2-yl)ethyl]ammonium dichloride;
CAS Number	7701-62-4 ;
PubChem CID	6243;
ChemSpider	6008 ;
UNII	JD3M24F66I;
ChEMBL	ChEMBL2104531 ;
CompTox Dashboard (EPA)	DTXSID0048395 ;
Chemical and physical data
Formula	C14H20Cl6N2
Molar mass	429.03 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES [Cl-].[Cl-].Clc1c2c(c(Cl)c(Cl)c1Cl)C[N+](C2)(C)CC[N+](C)(C)C;
	InChI InChI=1S/C14H20Cl4N2/c1-19(2,3)5-6-20(4)7-9-10(8-20)12(16)14(18)13(17)11(9)15/h5-8H2,1-4H3/q+2 ; Key:IXWDUZLHWJKVPX-UHFFFAOYSA-N ;
	(what is this?) (verify)

Chlorisondamine is a nicotinic acetylcholine receptor antagonist that produces both neuronal and ganglionic blockade.

Chlorisondamine has been shown to form noncovalent complexes with various biomolecules including sphingomyelin and other associated glycolipids.[1][2][3]

References

Woods, A. S.; Moyer, S. C.; Wang, H. Y. J.; Wise, R. A., "Interaction of chlorisondamine with the neuronal nicotinic acetylcholine receptor". Journal of Proteome Research 2003, 2 (2), 207–212.
Jackson, S. N.; Wang, H. Y. J.; Woods, A. S., "Direct tissue analysis of phospholipids in rat brain using MALDI-TOFMS and MALDI-ion mobility-TOFMS". Journal of the American Society for Mass Spectrometry 2005, 16 (2), 133–138.
Woods, A. S.; Ugarov, M.; Egan, T.; Koomen, J.; Gillig, K. J.; Fuhrer, K.; Gonin, M.; Schultz, J. A., "Lipid/peptide/nucleotide separation with MALDI-ion mobility-TOF MS". Analytical Chemistry 2004, 76 (8), 2187–2195.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[1] Woods, A. S.; Moyer, S. C.; Wang, H. Y. J.; Wise, R. A., "Interaction of chlorisondamine with the neuronal nicotinic acetylcholine receptor". Journal of Proteome Research 2003, 2 (2), 207–212.

[2] Jackson, S. N.; Wang, H. Y. J.; Woods, A. S., "Direct tissue analysis of phospholipids in rat brain using MALDI-TOFMS and MALDI-ion mobility-TOFMS". Journal of the American Society for Mass Spectrometry 2005, 16 (2), 133–138.

[3] Woods, A. S.; Ugarov, M.; Egan, T.; Koomen, J.; Gillig, K. J.; Fuhrer, K.; Gonin, M.; Schultz, J. A., "Lipid/peptide/nucleotide separation with MALDI-ion mobility-TOF MS". Analytical Chemistry 2004, 76 (8), 2187–2195.