Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific)

Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific)
Identifiers
EC number 2.5.1.89
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific) (EC 2.5.1.89) is an enzyme with systematic name geranylgeranyl-diphosphate:isopentenyl-diphosphate cistransferase (adding 7 isopentenyl units).[1] This enzyme catalyses the following chemical reaction

geranylgeranyl diphosphate + 7 isopentenyl diphosphate 7 diphosphate + tritrans,heptacis-undecaprenyl diphosphate

This enzyme is involved in the biosynthesis of the glycosyl carrier lipid in some archaebacteria.

References

  1. Hemmi, H.; Yamashita, S.; Shimoyama, T.; Nakayama, T.; Nishino, T. (2001). "Cloning, expression, and characterization of cis-polyprenyl diphosphate synthase from the thermoacidophilic archaeon Sulfolobus acidocaldarius". J. Bacteriol. 183 (1): 401–404. doi:10.1128/JB.183.1.401-404.2001. PMC 94892. PMID 11114943.
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