Tolimidone

Tolimidone
Clinical data
Synonyms CP-26154, MLR-1023
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
ECHA InfoCard 100.230.742 Edit this at Wikidata
Chemical and physical data
Formula C11H10N2O2
Molar mass 202.21 g/mol
3D model (JSmol)

Tolimidone (CP-26154; MLR-1023) is a compound which was discovered by scientists at Pfizer, was found to stimulate secretion of gastric mucosa, and was in development by Pfizer as a drug candidate to treat gastric ulcers but was abandoned.[1][2][3] After the patent on the compound expired, scientists at the company Melior Discovery identified it as a potential drug candidate for diabetes through a phenotypic screen and as of 2012 Melior was repurposing it for diabetes.[1][4] In June 2016, the company reported positive results from their Phase 2a clinical study in diabetic subjects[5]

References

  1. 1 2 Saporito, Michael S.; Lipinski, Christopher A.; Reaume, Andrew G. (2012). "Chapter 9:Phenotypic In Vivo Screening to Identify New, Unpredicted Indications for Existing Drugs and Drug Candidates". In Barratt, Michael J.; Frail, Donald E. Drug Repositioning: Bringing New Life to Shelved Assets and Existing Drugs. John Wiley & Sons. p. 270. ISBN 9781118274392.
  2. ↑ "Tolimidone". AdisInsight. Retrieved 26 August 2017.
  3. ↑ Lipinski, C. A.; Stam, J. G.; Pereira, J. N.; Ackerman, N. R.; Hess, H. J. (1980). "Bronchodilator and antiulcer phenoxypyrimidinones". Journal of Medicinal Chemistry. 23 (9): 1026–31. doi:10.1021/jm00183a012. PMID 7411545. Compound 3 has been assigned the nonproprietary (USAN) name tolimidone
  4. ↑ "Melior Discovery website press releases".
  5. ↑ "Melior Pharmaceuticals Announces Positive Phase 2A Results in Type 2 Diabetes Study".


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