Thujopsene synthase

Thujopsene synthase
Identifiers
EC number 4.2.3.79
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Thujopsene synthase (EC 4.2.3.79) is an enzyme with systematic name (2E,6E)-farnesyl diphosphate lyase (cyclizing, (+)-thujopsene-forming).[1][2] This enzyme catalyses the following chemical reaction

(2E,6E)-farnesyl diphosphate (+)-thujopsene + diphosphate

The recombinant enzyme from the plant Arabidopsis thaliana produces (+)-alpha-barbatene, (+)-thujopsene and (+)-beta-chamigrene.

References

  1. Wu, S.; Schoenbeck, M.A.; Greenhagen, B.T.; Takahashi, S.; Lee, S.; Coates, R.M.; Chappell, J. (2005). "Surrogate splicing for functional analysis of sesquiterpene synthase genes". Plant Physiol. 138: 1322–1333. doi:10.1104/pp.105.059386. PMC 1176406. PMID 15965019.
  2. Tholl, D.; Chen, F.; Petri, J.; Gershenzon, J.; Pichersky, E. (2005). "Two sesquiterpene synthases are responsible for the complex mixture of sesquiterpenes emitted from Arabidopsis flowers". Plant J. 42: 757–771. doi:10.1111/j.1365-313x.2005.02417.x. PMID 15918888.
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