Tentoxilysin
| Tentoxilysin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.4.24.68 | ||||||||
| CAS number | 107231-12-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Tentoxilysin (EC 3.4.24.68, tetanus neurotoxin) is an enzyme.[1][2][3][4][5] This enzyme catalyses the following chemical reaction
- Hydrolysis of -Gln76-Phe- bond in synaptobrevin
This cinc enzyme produced by Clostridium tetani.
References
- ↑ Fujii, N.; Kimura, K.; Yashiki, T.; Tsuzuki, K.; Moriishi, K.; Yokosawa, N.; Syuto, B.; Oguma, K. (1992). "A zinc-protease specific domain in botulinum and tetanus neurotoxins". Microbiol. Intern. 302 (3): 213–220. PMID 1376283.
- ↑ Schiavo, G.; Benfenati, F.; Poulain, B.; Rossetto, O.; Polverino de Laureto, P.; DasGupta, B.R.; Montecucco, C. (1992). "Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin". Nature. 359 (6398): 832–834. doi:10.1038/359832a0. PMID 1331807.
- ↑ Schiavo, G.; Rossetto, O.; Santucci, A.; DasGupta, B.R.; Montecucco, C. (1992). "Botulinum neurotoxins are zinc proteins". J. Biol. Chem. 267 (33): 23479–23483. PMID 1429690.
- ↑ Montecucco, C.; Schiavo, G. (1994). "Mechanism of action of tetanus and botulinum neurotoxins". Mol. Microbiol. 13 (1): 1–8. doi:10.1111/j.1365-2958.1994.tb00396.x. PMID 7527117.
- ↑ Schiavo, G.; Montecucco, C. (1995). "Tetanus and botulism neurotoxins". Methods Enzymol. 248: 643–652. doi:10.1016/0076-6879(95)48041-2. PMID 7674951.
External links
- Tentoxilysin at the US National Library of Medicine Medical Subject Headings (MeSH)
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