Succinate-semialdehyde dehydrogenase (acylating)

Succinate-semialdehyde dehydrogenase (acylating)
Identifiers
EC number 1.2.1.76
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Succinate-semialdehyde dehydrogenase (acylating) (EC 1.2.1.76, succinyl-coA reductase, coenzyme-A-dependent succinate-semialdehyde dehydrogenase) is an enzyme with systematic name succinate semialdehyde:NADP+ oxidoreductase (CoA-acylating).[1][2][3] This enzyme catalyses the following chemical reaction

succinate semialdehyde + CoA + NADP+ succinyl-CoA + NADPH + H+

Catalyses the NADPH-dependent reduction of succinyl-CoA to succinate semialdehyde.

References

  1. ↑ Sohling, B.; Gottschalk, G. (1993). "Purification and characterization of a coenzyme-A-dependent succinate-semialdehyde dehydrogenase from Clostridium kluyveri". Eur. J. Biochem. 212 (1): 121–127. doi:10.1111/j.1432-1033.1993.tb17641.x. PMID 8444151.
  2. ↑ Alber, B.; Olinger, M.; Rieder, A.; Kockelkorn, D.; Jobst, B.; Hugler, M.; Fuchs, G. (2006). "Malonyl-coenzyme A reductase in the modified 3-hydroxypropionate cycle for autotrophic carbon fixation in archaeal Metallosphaera and Sulfolobus spp". J. Bacteriol. 188: 8551–8559. doi:10.1128/JB.00987-06. PMC 1698253. PMID 17041055.
  3. ↑ Berg, I.A.; Kockelkorn, D.; Buckel, W.; Fuchs, G. (2007). "A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea". Science. 318: 1782–1786. doi:10.1126/science.1149976. PMID 18079405.
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