Sphingomyelin deacylase

Sphingomyelin deacylase
Identifiers
EC number 3.5.1.109
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Sphingomyelin deacylase (EC 3.5.1.109, SM deacylase, GcSM deacylase, glucosylceramide sphingomyelin deacylase, sphingomyelin glucosylceramide deacylase, SM glucosylceramide GCer deacylase, SM-GCer deacylase, SMGCer deacylase) is an enzyme with systematic name N-acyl-sphingosylphosphorylcholine amidohydrolase.[1][2][3] This enzyme catalyses the following chemical reaction

(1) an N-acyl-sphingosylphosphorylcholine + H2O a fatty acid + sphingosylphosphorylcholine;;
(2) a D-glucosyl-N-acylsphingosine + H2O a fatty acid + D-glucosyl-sphingosine

The enzyme is involved in the sphingolipid metabolism in the epidermis.

References

  1. ↑ Hara J, Higuchi K, Okamoto R, Kawashima M, Imokawa G (September 2000). "High-expression of sphingomyelin deacylase is an important determinant of ceramide deficiency leading to barrier disruption in atopic dermatitis". The Journal of Investigative Dermatology. 115 (3): 406–13. doi:10.1046/j.1523-1747.2000.00072.x. PMID 10951276.
  2. ↑ Higuchi K, Hara J, Okamoto R, Kawashima M, Imokawa G (September 2000). "The skin of atopic dermatitis patients contains a novel enzyme, glucosylceramide sphingomyelin deacylase, which cleaves the N-acyl linkage of sphingomyelin and glucosylceramide". The Biochemical Journal. 350 Pt 3: 747–56. doi:10.1042/0264-6021:3500747. PMC 1221306. PMID 10970788.
  3. ↑ Ishibashi M, Arikawa J, Okamoto R, Kawashima M, Takagi Y, Ohguchi K, Imokawa G (March 2003). "Abnormal expression of the novel epidermal enzyme, glucosylceramide deacylase, and the accumulation of its enzymatic reaction product, glucosylsphingosine, in the skin of patients with atopic dermatitis". Laboratory Investigation; A Journal of Technical Methods and Pathology. 83 (3): 397–408. doi:10.1097/01.lab.0000059931.66821.92. PMID 12649340.
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