Guanine deaminase

GDA
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGDA, guanine deaminase, CYPIN, GUANASE, NEDASIN, Guanine deaminase, GAH
External IDsMGI: 95678 HomoloGene: 3171 GeneCards: GDA
Gene location (Human)
Chr.Chromosome 9 (human)[1]
Band9q21.13Start72,114,595 bp[1]
End72,257,193 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

9615

14544

Ensembl

ENSG00000119125

ENSMUSG00000058624

UniProt

Q9Y2T3

Q9R111

RefSeq (mRNA)

NM_010266

RefSeq (protein)

NP_034396

Location (UCSC)Chr 9: 72.11 – 72.26 MbChr 19: 21.39 – 21.47 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Guanine deaminase also known as cypin, guanase, guanine aminase, GAH, and guanine aminohydrolase is an aminohydrolase enzyme which converts guanine to xanthine.[5][6][7] Cypin is a major cytosolic protein that interacts with PSD-95. It promotes localized microtubule assembly in neuronal dendrites.[8]

Xanthine synthesis from guanine

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000119125 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000058624 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Hitchings GH, Falco EA (Oct 1944). "The Identification of Guanine in Extracts of Girella Nigricans: The Specificity of Guanase". Proceedings of the National Academy of Sciences of the United States of America. 30 (10): 294–7. doi:10.1073/pnas.30.10.294. PMC 1078714. PMID 16578130.
  6. ↑ Kalckar HM (1947). "Differential spectrophotometry of purine compounds by means of specific enzymes; studies of the enzymes of purine metabolism". J. Biol. Chem. 167 (2): 461–75. PMID 20285041.
  7. ↑ Rabinowitz JC, Barker HA (Jan 1956). "Purine fermentation by Clostridium cylindrosporum. II. Purine transformations". The Journal of Biological Chemistry. 218 (1): 161–73. PMID 13278325.
  8. ↑ Firestein BL, Firestein BL, Brenman JE, Aoki C, Sanchez-Perez AM, El-Husseini AE, Bredt DS (1999). "Cypin: a cytosolic regulator of PSD-95 postsynaptic targeting". Neuron. 24 (3): 659–72. doi:10.1016/S0896-6273(00)81120-4. PMID 10595517.
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