SNX3

SNX3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2YPS, 2MXC
Identifiers
Aliases	SNX3, Grd19, MCOPS8, SDP3, sorting nexin 3
External IDs	MGI: 1860188 HomoloGene: 36144 GeneCards: SNX3
Gene location (Human)
Chr.	Chromosome 6 (human)[1]
End	108,261,260 bp[1]
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)[2]
End	42,535,381 bp[2]
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• phosphatidylinositol-3-phosphate binding; • phosphatidylinositol-3,5-bisphosphate binding; • phosphatidylinositol-4-phosphate binding; • phosphatidylinositol-5-phosphate binding; • protein binding; • phosphatidylinositol binding; • protein phosphatase binding; • lipid binding;
Cellular component	• cytoplasm; • cytosol; • endosome; • early endosome membrane; • early phagosome; • retromer complex; • early endosome; • phagocytic vesicle; • extracellular exosome; • cytoplasmic vesicle; • clathrin-coated vesicle; • extrinsic component of membrane; • endosome membrane;
Biological process	• protein to membrane docking; • negative regulation of viral entry into host cell; • negative regulation of phagocytosis; • response to bacterium; • negative regulation of protein catabolic process; • negative regulation of early endosome to late endosome transport; • membrane invagination; • regulation of Wnt signaling pathway; • intralumenal vesicle formation; • negative regulation of protein transport; • positive regulation of neuron projection development; • protein transport; • Wnt signaling pathway; • protein deubiquitination; • transport;
	Sources:Amigo / QuickGO
Orthologs
	8724
	54198
	ENSG00000112335
	ENSMUSG00000019804
	O60493
	O70492
	NM_152828; NM_001300928; NM_001300929; NM_003795; NM_152827
	NM_017472
	NP_001287857; NP_001287858; NP_003786; NP_690040
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Sorting nexin-3 is a protein that in humans is encoded by the SNX3 gene.^[5]^[6]

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like most family members. This protein interacts with phosphatidylinositol-3-phosphate, and is involved in protein trafficking.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000112335 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019804 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Haft CR, de la Luz Sierra M, Barr VA, Haft DH, Taylor SI (Dec 1998). "Identification of a Family of Sorting Nexin Molecules and Characterization of Their Association with Receptors". Mol Cell Biol. 18 (12): 7278–87. doi:10.1128/mcb.18.12.7278. PMC 109309. PMID 9819414.
1 2 "Entrez Gene: SNX3 sorting nexin 3".

Parks WT, Frank DB, Huff C, et al. (2001). "Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases". J. Biol. Chem. 276 (22): 19332–9. doi:10.1074/jbc.M100606200. PMID 11279102.
Xu Y, Hortsman H, Seet L, et al. (2001). "SNX3 regulates endosomal function through its PX-domain-mediated interaction with PtdIns(3)P". Nat. Cell Biol. 3 (7): 658–66. doi:10.1038/35083051. PMID 11433298.
Vervoort VS, Viljoen D, Smart R, et al. (2003). "Sorting nexin 3 (SNX3) is disrupted in a patient with a translocation t(6;13)(q21;q12) and microcephaly, microphthalmia, ectrodactyly, prognathism (MMEP) phenotype". J. Med. Genet. 39 (12): 893–9. doi:10.1136/jmg.39.12.893. PMC 1757218. PMID 12471201.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Kumar RA, Everman DB, Morgan CT, et al. (2007). "Absence of mutations in NR2E1 and SNX3 in five patients with MMEP (microcephaly, microphthalmia, ectrodactyly, and prognathism) and related phenotypes". BMC Med. Genet. 8: 48. doi:10.1186/1471-2350-8-48. PMC 1950490. PMID 17655765.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000112335 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019804 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid9819414-5] Haft CR, de la Luz Sierra M, Barr VA, Haft DH, Taylor SI (Dec 1998). "Identification of a Family of Sorting Nexin Molecules and Characterization of Their Association with Receptors". Mol Cell Biol. 18 (12): 7278–87. doi:10.1128/mcb.18.12.7278. PMC 109309. PMID 9819414.

[entrez-6] 1 2 "Entrez Gene: SNX3 sorting nexin 3".

Sorting nexins
SNX-BAR	SNX1 SNX2 SNX4 SNX5 SNX6 SNX7 SNX8 SNX9 SNX18 SNX30 SNX32 SNX33
SNX-PX	SNX3 SNX10 SNX11 SNX12 SNX16 SNX20 SNX21 SNX22 SNX24 SNX29
SNX-Other	SNX13 SNX14 SNX15 SNX17 SNX19 SNX23 SNX25 SNX26 SNX27 SNX28 SNX31
Related articles	PX domain BAR domain Retromer

SNX3

References

Further reading