SMC4

SMC4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSMC4, CAP-C, CAPC, SMC-4, SMC4L1, hCAP-C, structural maintenance of chromosomes 4
External IDsMGI: 1917349 HomoloGene: 4015 GeneCards: SMC4
Gene location (Human)
Chr.Chromosome 3 (human)[1]
Band3q25.33Start160,399,274 bp[1]
End160,434,962 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10051

70099

Ensembl

ENSG00000113810

ENSMUSG00000034349

UniProt

Q9NTJ3

Q8CG47

RefSeq (mRNA)

NM_001002799
NM_001002800
NM_001288753
NM_005496

NM_133786
NM_001356976

RefSeq (protein)

NP_001002800
NP_001275682
NP_005487

NP_598547
NP_001343905

Location (UCSC)Chr 3: 160.4 – 160.43 MbChr 3: 69 – 69.03 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Structural maintenance of chromosomes protein 4 (SMC-4) also known as chromosome-associated polypeptide C (CAP-C) or XCAP-C homolog is a protein that in humans is encoded by the SMC4 gene.[5][6][7] SMC-4 is a core subunit of condensin I and II, large protein complexes involved in chromosome condensation.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000113810 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034349 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Schmiesing JA, Ball AR Jr, Gregson HC, Alderton JM, Zhou S, Yokomori K (Nov 1998). "Identification of two distinct human SMC protein complexes involved in mitotic chromosome dynamics". Proc Natl Acad Sci U S A. 95 (22): 12906–11. doi:10.1073/pnas.95.22.12906. PMC 23650. PMID 9789013.
  6. ↑ Nishiwaki T, Daigo Y, Kawasoe T, Nagasawa Y, Ishiguro H, Fujita M, Furukawa Y, Nakamura Y (Jun 1999). "Isolation and characterization of a human cDNA homologous to the Xenopus laevis XCAP-C gene belonging to the structural maintenance of chromosomes (SMC) family". J Hum Genet. 44 (3): 197–202. doi:10.1007/s100380050142. PMID 10319587.
  7. ↑ "Entrez Gene: SMC4 structural maintenance of chromosomes 4".

Further reading

  • Hirano T (2002). "The ABCs of SMC proteins: two-armed ATPases for chromosome condensation, cohesion, and repair". Genes Dev. 16 (4): 399–414. doi:10.1101/gad.955102. PMID 11850403.
  • Ball Jr AR, Yokomori K (2001). "The structural maintenance of chromosomes (SMC) family of proteins in mammals". Chromosome Res. 9 (2): 85–96. doi:10.1023/A:1009287518015. PMID 11321372.
  • Ham MF, Takakuwa T, Rahadiani N, et al. (2007). "Condensin mutations and abnormal chromosomal structures in pyothorax-associated lymphoma". Cancer Sci. 98 (7): 1041–7. doi:10.1111/j.1349-7006.2007.00500.x. PMID 17488335.
  • Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
  • Geiman TM, Sankpal UT, Robertson AK, et al. (2004). "Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery". Nucleic Acids Res. 32 (9): 2716–29. doi:10.1093/nar/gkh589. PMC 419596. PMID 15148359.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Kimura K, Cuvier O, Hirano T (2001). "Chromosome condensation by a human condensin complex in Xenopus egg extracts". J. Biol. Chem. 276 (8): 5417–20. doi:10.1074/jbc.C000873200. PMID 11136719.
  • Schmiesing JA, Gregson HC, Zhou S, Yokomori K (2000). "A Human Condensin Complex Containing hCAP-C–hCAP-E and CNAP1, a Homolog of Xenopus XCAP-D2, Colocalizes with Phosphorylated Histone H3 during the Early Stage of Mitotic Chromosome Condensation". Mol. Cell. Biol. 20 (18): 6996–7006. doi:10.1128/MCB.20.18.6996-7006.2000. PMC 88774. PMID 10958694.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.


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