Gem-associated protein 7

GEMIN7
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGEMIN7, SIP3, gem nuclear organelle associated protein 7
External IDsMGI: 1916981 HomoloGene: 11668 GeneCards: GEMIN7
Gene location (Human)
Chr.Chromosome 19 (human)[1]
Band19q13.32Start45,079,195 bp[1]
End45,091,524 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

79760

69731

Ensembl

ENSG00000142252

ENSMUSG00000044709

UniProt

Q9H840

Q9CWY4

RefSeq (mRNA)

NM_001007269
NM_001007270
NM_024707
NM_001319054
NM_001319055

NM_027189

RefSeq (protein)

NP_001007270
NP_001007271
NP_001305983
NP_001305984
NP_078983

NP_081465

Location (UCSC)Chr 19: 45.08 – 45.09 MbChr 7: 19.56 – 19.58 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Gem-associated protein 7 is a protein that in humans is encoded by the GEMIN7 gene.[5][6]The gem-associated proteins are those found in the gems of Cajal bodies.

Function

The protein encoded by this gene is a component of the core SMN complex, which is required for pre-mRNA splicing in the nucleus. The encoded protein is found in the nucleoplasm, in nuclear "gems" (Gemini of Cajal bodies), and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene.[6]

Interactions

Gem-associated protein 7 has been shown to interact with SMN1[5][7] and Gem-associated protein 6.[5][8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000142252 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000044709 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. 1 2 3 Baccon J, Pellizzoni L, Rappsilber J, Mann M, Dreyfuss G (Aug 2002). "Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex". The Journal of Biological Chemistry. 277 (35): 31957–62. doi:10.1074/jbc.M203478200. PMID 12065586.
  6. 1 2 "Entrez Gene: GEMIN7 gem (nuclear organelle) associated protein 7".
  7. ↑ Pellizzoni L, Baccon J, Rappsilber J, Mann M, Dreyfuss G (Mar 2002). "Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component". The Journal of Biological Chemistry. 277 (9): 7540–5. doi:10.1074/jbc.M110141200. PMID 11748230.
  8. ↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

Further reading

  • Carissimi C, Saieva L, Gabanella F, Pellizzoni L (Dec 2006). "Gemin8 is required for the architecture and function of the survival motor neuron complex". The Journal of Biological Chemistry. 281 (48): 37009–16. doi:10.1074/jbc.M607505200. PMID 17023415.
  • Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
  • Grimmler M, Otter S, Peter C, Müller F, Chari A, Fischer U (Oct 2005). "Unrip, a factor implicated in cap-independent translation, associates with the cytosolic SMN complex and influences its intracellular localization". Human Molecular Genetics. 14 (20): 3099–111. doi:10.1093/hmg/ddi343. PMID 16159890.
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