SFI1

SFI1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSFI1, PISD, PPP1R139, hSfi1p, SFI1 centrin binding protein
External IDsMGI: 1926137 HomoloGene: 12707 GeneCards: SFI1
Gene location (Human)
Chr.Chromosome 22 (human)[1]
Band22q12.2Start31,488,688 bp[1]
End31,618,586 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

9814

78887

Ensembl

ENSG00000198089

ENSMUSG00000023764

UniProt

A8K8P3

Q3UZY0

RefSeq (mRNA)

NM_001007467
NM_001258325
NM_001258326
NM_001258327
NM_014775

NM_030207
NM_001363222
NM_001363223
NM_001363224

RefSeq (protein)

NP_001007468
NP_001245254
NP_001245255
NP_001245256
NP_055590

NP_084483
NP_001350151
NP_001350152
NP_001350153

Location (UCSC)Chr 22: 31.49 – 31.62 MbChr 11: 3.13 – 3.19 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sfi1 homolog, spindle assembly associated (yeast) is a protein that in humans is encoded by the SFI1 gene. [5] It localizes to the centriole, and its S. pombe ortholog has been shown to be involved in spindle pole body duplication.[6] SFI1 forms a complex with centrin 2.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000198089 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000023764 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ "Entrez Gene: Sfi1 homolog, spindle assembly associated (yeast)". Retrieved 2014-06-25.
  6. ↑ Elserafy M, Šarić M, Neuner A, Lin TC, Zhang W, Seybold C, Sivashanmugam L, Schiebel E (July 2014). "Molecular mechanisms that restrict yeast centrosome duplication to one event per cell cycle". Current Biology. 24 (13): 1456–66. doi:10.1016/j.cub.2014.05.032. PMID 24954044.
  7. ↑ Martinez-Sanz J, Kateb F, Assairi L, Blouquit Y, Bodenhausen G, Abergel D, Mouawad L, Craescu CT (January 2010). "Structure, dynamics and thermodynamics of the human centrin 2/hSfi1 complex". Journal of Molecular Biology. 395 (1): 191–204. doi:10.1016/j.jmb.2009.10.041. PMID 19857500.

Further reading

  • Martinez-Sanz J, Kateb F, Assairi L, Blouquit Y, Bodenhausen G, Abergel D, Mouawad L, Craescu CT (January 2010). "Structure, dynamics and thermodynamics of the human centrin 2/hSfi1 complex". Journal of Molecular Biology. 395 (1): 191–204. doi:10.1016/j.jmb.2009.10.041. PMID 19857500.
  • Mayor T, Stierhof YD, Tanaka K, Fry AM, Nigg EA (November 2000). "The centrosomal protein C-Nap1 is required for cell cycle-regulated centrosome cohesion". The Journal of Cell Biology. 151 (4): 837–46. doi:10.1083/jcb.151.4.837. PMC 2169446. PMID 11076968.
  • Petretti C, Savoian M, Montembault E, Glover DM, Prigent C, Giet R (April 2006). "The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation". EMBO Reports. 7 (4): 418–24. doi:10.1038/sj.embor.7400639. PMC 1456919. PMID 16462731.
  • Casenghi M, Meraldi P, Weinhart U, Duncan PI, Körner R, Nigg EA (July 2003). "Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation". Developmental Cell. 5 (1): 113–25. doi:10.1016/S1534-5807(03)00193-X. PMID 12852856.
  • Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". The EMBO Journal. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846. PMID 11101529.
  • Kilmartin JV (September 2003). "Sfi1p has conserved centrin-binding sites and an essential function in budding yeast spindle pole body duplication". The Journal of Cell Biology. 162 (7): 1211–21. doi:10.1083/jcb.200307064. PMC 2173958. PMID 14504268.
  • Hendrickx A, Beullens M, Ceulemans H, Den Abt T, Van Eynde A, Nicolaescu E, Lesage B, Bollen M (April 2009). "Docking motif-guided mapping of the interactome of protein phosphatase-1". Chemistry & Biology. 16 (4): 365–71. doi:10.1016/j.chembiol.2009.02.012. PMID 19389623.
  • Takahashi M, Yamagiwa A, Nishimura T, Mukai H, Ono Y (September 2002). "Centrosomal proteins CG-NAP and kendrin provide microtubule nucleation sites by anchoring gamma-tubulin ring complex". Molecular Biology of the Cell. 13 (9): 3235–45. doi:10.1091/mbc.E02-02-0112. PMC 124155. PMID 12221128.
  • Golsteyn RM, Mundt KE, Fry AM, Nigg EA (June 1995). "Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function". The Journal of Cell Biology. 129 (6): 1617–28. doi:10.1083/jcb.129.6.1617. PMC 2291169. PMID 7790358.
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