CEP170

CEP170
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCEP170, FAM68A, KAB, KIAA0470, centrosomal protein 170
External IDsMGI: 1918348 HomoloGene: 22844 GeneCards: CEP170
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1q43Start243,124,428 bp[1]
End243,255,348 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

9859

545389

Ensembl

ENSG00000143702
ENSG00000276725

ENSMUSG00000057335

UniProt

Q5SW79

Q6A065

RefSeq (mRNA)

NM_001042404
NM_001042405
NM_014812

NM_001024722
NM_001099637

RefSeq (protein)

NP_001035863
NP_001035864
NP_055627

NP_001093107

Location (UCSC)Chr 1: 243.12 – 243.26 MbChr 1: 176.73 – 176.81 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Centrosomal protein 170kDa, also known as CEP170, is a protein that in humans is encoded by the CEP170 gene.[5][6]

Function

The product of this gene is a component of the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. During interphase, the encoded protein localizes to the sub-distal appendages of mature centrioles, which are microtubule-based structures thought to help organize centrosomes. During mitosis, the protein associates with spindle microtubules near the centrosomes. The protein interacts with the intraflagellar transport protein 81 (IFT81), the SH3-domain containing protein PRAX-1, and is phosphorylated by cyclin dependent kinase 1 ( Cdk1 ) and polo-like kinase 1 ( PLK1 ), and functions in maintaining Microtubule organization, cell morphology and cilium stability.[5]

The human genome contains a putative transcribed pseudogene. Several alternatively spliced transcript variants of this gene have been found, but the full-length nature of some of these variants has not been determined.[5]

References

  1. 1 2 3 ENSG00000276725 GRCh38: Ensembl release 89: ENSG00000143702, ENSG00000276725 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000057335 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. 1 2 3 "Entrez Gene: CEP170 centrosomal protein 170kDa".
  6. ↑ Guarguaglini G, Duncan PI, Stierhof YD, Holmström T, Duensing S, Nigg EA (March 2005). "The forkhead-associated domain protein Cep170 interacts with Polo-like kinase 1 and serves as a marker for mature centrioles". Molecular Biology of the Cell. 16 (3): 1095–107. doi:10.1091/mbc.E04-10-0939. PMC 551476. PMID 15616186.

Further reading

  • Andersen JS, Wilkinson CJ, Mayor T, et al. (2003). "Proteomic characterization of the human centrosome by protein correlation profiling". Nature. 426 (6966): 570–4. doi:10.1038/nature02166. PMID 14654843.
  • Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
  • Guarguaglini G, Duncan PI, Stierhof YD, et al. (2005). "The forkhead-associated domain protein Cep170 interacts with Polo-like kinase 1 and serves as a marker for mature centrioles". Mol. Biol. Cell. 16 (3): 1095–107. doi:10.1091/mbc.E04-10-0939. PMC 551476. PMID 15616186.
  • Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells". J. Proteome Res. 4 (4): 1339–46. doi:10.1021/pr050048h. PMID 16083285.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
  • Lamla S (2009). "Functional characterisation of the centrosomal protein Cep170". Dissertation, LMU Muenchen: Fakultät für Biologie. URN nbn:de:bvb:19-97838.


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