Pyruvate dehydrogenase (NADP+)

Pyruvate dehydrogenase (NADP+)
Identifiers
EC number 1.2.1.51
CAS number 93389-35-6
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

Pyruvate dehydrogenase (NADP+) EC 1.2.1.51 is an enzyme that should not be confused with Pyruvate dehydrogenase (acetyltransferase) EC 1.2.4.1.[1][2]

It catalyzes the following reaction:

Pyruvate + Coenzyme A + NADP+ ⇒ acetyl-CoA + NADPH + H+ + CO2

References

  1. ↑ Inui 1984, pp. 931–934.
  2. ↑ Inui 1987, pp. 9130–9135.

Bibliography

  • Ctrnacta, V.; Ault, J. G.; Stejskal, F.; Keithly, J. S. (2006). "Localization of pyruvate: NADP+ oxidoreductase in sporozoites of Cryptosporidium parvum". J. Eukaryot. Microbiol. 53 (4): 225–231. doi:10.1111/j.1550-7408.2006.00099.x. PMID 16872290.
  • Inui, H.; Miyatake, K.; Nakano, Y.; Kitaoka, S. (1984). "Occurrence of oxygen-sensitive, NADP+-dependent pyruvate dehydrogenase in mitochondria of Euglena gracilis". J. Biochem. 96 (3): 931–934. doi:10.1093/oxfordjournals.jbchem.a134913. PMID 6438078.
  • Inui, H.; Miyatake, K.; Nakano, Y.; Kitaoka, S. (1985). "The physiological role of oxygen-sensitive pyruvate dehydrogenase in mitochondrial fatty acid synthesis in Euglena gracilis". Arch. Biochem. Biophys. 237 (2): 423–429. doi:10.1016/0003-9861(85)90295-4. PMID 3919646.
  • Inui, H.; Miyatake, K.; Nakano, Y.; Kitaoka, S. (1989). "Pyruvate: NADP+ oxidoreductase from Euglena gracilis: the kinetic properties of the enzyme". Arch. Biochem. Biophys. 274 (2): 434–442. doi:10.1016/0003-9861(89)90456-6. PMID 2508561.
  • Inui, H.; Miyatake, K.; Nakano, Y.; Kitaoka, S. (1990). "Pyruvate: NADP+ oxidoreductase from Euglena gracilis: mechanism of O2-inactivation of the enzyme and its stability in the aerobe". Arch. Biochem. Biophys. 280 (2): 292–298. doi:10.1016/0003-9861(90)90332-S. PMID 2114824.
  • Inui, H.; Ono, K.; Miyatake, K.; Nakano, Y.; Kitaoka, S. (1987). "Purification and characterization of pyruvate: NADP+ oxidoreductase in Euglena gracilis". J. Biol. Chem. 262 (19): 9130–9135. PMID 3110154.
  • Inui, H.; Yamaji, R.; Saidoh, H.; Miyatake, K.; Nakano, Y.; Kitaoka, S. (1991). "Pyruvate: NADP+ oxidoreductase from Euglena gracilis: limited proteolysis of the enzyme with trypsin". Arch. Biochem. Biophys. 286 (1): 270–276. doi:10.1016/0003-9861(91)90040-P. PMID 1910287.
  • Lochmeyer, C.; Fuchs, G. (1990). "NADP+-specific 2-oxoglutarate dehydrogenase in denitrifying Pseudomonas species". Arch. Microbiol. 153 (3): 226–229. doi:10.1007/BF00249072.
  • Nakazawa, M.; Inui, H.; Yamaji, R.; Yamamoto, T.; Takenaka, S.; Ueda, M.; Nakano, Y.; Miyatake, K. (2000). "The origin of pyruvate: NADP oxidoreductase in mitochondria of Euglena gracilis". FEBS Lett. 479 (3): 155–156. doi:10.1016/S0014-5793(00)01882-2. PMID 11023353.
  • Nakazawa, M.; Takenaka, S.; Ueda, M.; Inui, H.; Nakano, Y.; Miyatake, K. (2003). "Pyruvate: NADP+ oxidoreductase is stabilized by its cofactor, thiamin pyrophosphate, in mitochondria of Euglena gracilis". Arch. Biochem. Biophys. 411 (2): 183–188. doi:10.1016/S0003-9861(02)00749-X. PMID 12623066.
  • Sawada, K.; Taki, A.; Yamakawa, T.; Seki, M. (2009). "Key role for transketolase activity in erythritol production by Trichosporonoides megachiliensis SN-G42". J. Biosci. Bioeng. 108 (5): 385–390. doi:10.1016/j.jbiosc.2009.05.008. PMID 19804861.

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