Peptidyl-glutamate 4-carboxylase

Peptidyl-glutamate 4-carboxylase
Identifiers
EC number 4.1.1.90
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Peptidyl-glutamate 4-carboxylase (EC 4.1.1.90, vitamin K-dependent carboxylase, gamma-glutamyl carboxylase) is an enzyme with systematic name peptidyl-glutamate 4-carboxylase (2-methyl-3-phytyl-1,4-naphthoquinone-epoxidizing).[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction

peptidyl-4-carboxyglutamate + 2,3-epoxyphylloquinone + H2O peptidyl-glutamate + CO2 + O2 + phylloquinone

The enzyme can use various vitamin-K derivatives, including menaquinone.

References

  1. ↑ Dowd, P.; Hershline, R.; Ham, S.W.; Naganathan, S. (1995). "Vitamin K and energy transduction: a base strength amplification mechanism". Science. 269 (5231): 1684–1691. doi:10.1126/science.7569894. PMID 7569894.
  2. ↑ Furie, B.; Bouchard, B.A.; Furie, B.C. (1999). "Vitamin K-dependent biosynthesis of γ-carboxyglutamic acid". Blood. 93 (6): 1798–1808. PMID 10068650.
  3. ↑ Rishavy, M.A.; Hallgren, K.W.; Yakubenko, A.V.; Shtofman, R.L.; Runge, K.W.; Berkner, K.L. (2006). "Bronsted analysis reveals Lys218 as the carboxylase active site base that deprotonates vitamin K hydroquinone to initiate vitamin K-dependent protein carboxylation". Biochemistry. 45 (44): 13239–13248. doi:10.1021/bi0609523. PMID 17073445.
  4. ↑ Silva, P.J.; Ramos, M.J. (2007). "Reaction mechanism of the vitamin K-dependent glutamate carboxylase: a computational study". J. Phys. Chem. B. 111: 12883–12887. doi:10.1021/jp0738208. PMID 17935315.
  5. ↑ Decottignies-Le Maréchal, P.; Ducrocq, C.; Marquet, A.; Azerad, R. (1984). "The stereochemistry of hydrogen abstraction in vitamin K-dependent carboxylation". J. Biol. Chem. 259 (24): 15010–15012. PMID 6150930.
  6. ↑ Dubois, J.; Dugave, C.; Foures, C.; Kaminsky, M.; Tabet, J.C.; Bory, S.; Gaudry, M.; Marquet, A. (1991). "Vitamin K dependent carboxylation: determination of the stereochemical course using 4-fluoroglutamyl-containing substrate". Biochemistry. 30 (43): 10506–10512. doi:10.1021/bi00107a020. PMID 1931973.
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