Pentolinium

Pentolinium
Identifiers
CAS Number
PubChem CID
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UNII
ChEMBL
Chemical and physical data
Formula C15H32N2
Molar mass 240.43 g/mol

Pentolinium (Pentolinium tartrate also known as ANSOLYSEN)[1] is a ganglionic blocking agent which acts as a nicotinic acetylcholine receptor antagonist. It can be used as an antihypertensive drug during surgery or to control hypertensive crises. It works by binding to the acetylcholine receptor of adrenergic nerves and thereby inhibiting the release of noradrenaline and adrenaline. Blocking this receptor leads to smooth muscle relaxation and vasodilation.

Overview

It's molecular formula is (C15H32N2)2+.[2]

Route of administration & dosage

Pentolinium can be given orally (20mg three times a day), injected intramuscularly, or administered intravenously.[3]

Use

Rauwolfia, used in combination with hexamethonium, is effective in the outpatient management of moderate to severe hypertension, with satisfactory orthostatic reduction in blood pressure but there are significant untoward effects attributable to the use of the hexamethonium. Pentolinium has been reported to offer more prolonged ganglionic blockade and has less severe untoward effects than hexamethonium.[4]

References

  1. ↑ http://jamanetwork.com/journals/jama/article-abstract/299870
  2. ↑ https://pubchem.ncbi.nlm.nih.gov/compound/Pentolinium#section=Top
  3. ↑ R.D. Budhiraja (2009). Elementary Pharmacology & Toxicology. Popular Prakashan. p. 189. ISBN 97881-7991-472-4.
  4. ↑ http://www.nejm.org/doi/full/10.1056/NEJM195510062531404
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