Pentachlorophenol monooxygenase

Pentachlorophenol monooxygenase
Identifiers
EC number 1.14.13.50
CAS number 136111-57-4
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Pentachlorophenol monooxygenase (EC 1.14.13.50, pentachlorophenol dechlorinase, pentachlorophenol dehalogenase, pentachlorophenol 4-monooxygenase, PCP hydroxylase, pentachlorophenol hydroxylase, PcpB, PCB 4-monooxygenase, PCB4MO) is an enzyme with systematic name pentachlorophenol,NADPH:oxygen oxidoreductase (hydroxylating, dechlorinating).[1][2][3][4][5] This enzyme catalyses the following chemical reaction

(1) pentachlorophenol + 2 NADPH + H+ + O2 2,3,5,6-tetrachlorohydroquinone + 2 NADP+ + chloride + H2O
(2) 2,3,5,6-tetrachlorophenol + NADPH + H+ + O2 2,3,5,6-tetrachlorohydroquinone + NADP+ + H2O

Pentachlorophenol monooxygenase is a flavoprotein (FAD).

References

  1. ↑ Schenk T, Müller R, Mörsberger F, Otto MK, Lingens F (October 1989). "Enzymatic dehalogenation of pentachlorophenol by extracts from Arthrobacter sp. strain ATCC 33790". Journal of Bacteriology. 171 (10): 5487–91. PMC 210388. PMID 2793827.
  2. ↑ Xun L, Topp E, Orser CS (May 1992). "Diverse substrate range of a Flavobacterium pentachlorophenol hydroxylase and reaction stoichiometries". Journal of Bacteriology. 174 (9): 2898–902. PMC 205942. PMID 1569020.
  3. ↑ Xun L, Topp E, Orser CS (September 1992). "Confirmation of oxidative dehalogenation of pentachlorophenol by a Flavobacterium pentachlorophenol hydroxylase". Journal of Bacteriology. 174 (17): 5745–7. PMC 206524. PMID 1512208.
  4. ↑ Lange CC, Schneider BJ, Orser CS (February 1996). "Verification of the role of PCP 4-monooxygenase in chlorine elimination from pentachlorophenol by Flavobacterium sp. strain ATCC 39723". Biochemical and Biophysical Research Communications. 219 (1): 146–9. doi:10.1006/bbrc.1996.0196. PMID 8619798.
  5. ↑ Nakamura T, Motoyama T, Hirono S, Yamaguchi I (August 2004). "Identification, characterization, and site-directed mutagenesis of recombinant pentachlorophenol 4-monooxygenase". Biochimica et Biophysica Acta. 1700 (2): 151–9. doi:10.1016/j.bbapap.2004.04.008. PMID 15262224.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.